155956-28-8Relevant articles and documents
N-acyl 'Quat' pyrrolidinone auxiliary as a chiral amide equivalent via direct aminolysis
Davies, Stephen G.,Dixon, Darren J.
, p. 963 - 964 (1998)
A novel route into chiral amides is achieved through the efficient, non-racemising, cleavage of N-acyl side chains from a 'Quat' pyrrolidinone chiral auxiliary using a range of N-nucleophiles.
N-acyl 'Quat' pyrrolidinone auxiliary as a chiral amide equivalent via direct aminolysis
Davies, Stephen G.,Dixon, Darren J.
, p. 1869 - 1876 (2007/10/03)
A novel route to chiral amides through the efficient, non-racemising, cleavage of N-acyl side chains from a 'Quat' chiral auxiliary using N-centred nucleophiles is described. The synthetic utility of the procedure is then highlighted by the preparation of a range of succinamide and succinimide derivatives and through the synthesis of the natural product (S)-(+)-amphetamine via a stereospecific Hofman type degradation using a hypervalent iodine reagent.
