163756-60-3

Basic information

• Product Name: (+)-(S)-3,3-dimethyl-5-{[(4-methylphenyl)sulfonyloxy]methyl}pyrrolidin-2-one
• Synonyms: (+)-(S)-3,3-dimethyl-5-{[(4-methylphenyl)sulfonyloxy]methyl}pyrrolidin-2-one
• CAS NO: 163756-60-3
• Molecular Weight: 297.375
• Mol File: 163756-60-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (+)-(S)-3,3-dimethyl-5-{[(4-methylphenyl)sulfonyloxy]methyl}pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(S)-3,3-dimethyl-5-{[(4-methylphenyl)sulfonyloxy]methyl}pyrrolidin-2-one(163756-60-3)
• EPA Substance Registry System: (+)-(S)-3,3-dimethyl-5-{[(4-methylphenyl)sulfonyloxy]methyl}pyrrolidin-2-one(163756-60-3)

Safety Data

• Hazardous Substances Data: 163756-60-3(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 156088-46-9 (5S)-3,3-dimethyl-5-hydroxymethylpyrrolidin-2-one 
• 99208-71-6 (5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane 
• 156088-45-8 (5S)-1-aza-2,2-dimethyl-7,7-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane 
• 17342-08-4 (S)-Pyroglutaminol 
• 98-79-3 L-Pyroglutamic acid 
• 7149-65-7 ethyl (S)-pyroglutamate 

Downstream Products

• 260781-95-1 (+)-(S)-5-[(4-diphenylphosphino)methyl]-3,3-dimethylpyrrolidin-2-one 
• 155956-29-9 (5R)-(-)-(1'-oxo-3'-phenylpropyl)-5,3,3-trimethylpyrrolidin-2-one 
• 155956-27-7 (2'R,3'R,5R)-(-)-1-(3'-hydroxy-2'-methyl-3'-phenyl-1'-oxopropyl)-3,3,5-trimethyl-2-pyrrolidinone 
• 155956-28-8 (2'S,5R)-1-(1'-oxo-2'-phenylmethylpropyl)-3,3,5-trimethylpyrrolidin-2-one 
• 163756-70-5 (5R)-(-)-(1'-oxo-3'-phenylpropyl)-5-ethyl-3,3-dimethylpyrrolidin-2-one 
• 260782-06-7 (S)-5-(Dicyclohexyl-phosphinoylmethyl)-3,3-dimethyl-pyrrolidin-2-one 

Relevant articles and documents

COMPOUNDS COMPRISING A LACTAM OR A LACTAM DERIVATIVE MOIETY, PROCESSES FOR MAKING THEM, AND THEIR USES

The present invention relates to compounds of formula (I) comprising a lactam or a lactam derivative moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as pharmaceuticals.

Approach to enantioselective conjugate addition of organocopper reagents to cycloalkenones by the aid of chiral lactam bearing phosphine group

The chiral lactam-phosphine ligand and copper salt mediated asymmetric conjugate addition reaction of butylmagnesium chloride and diethylzinc with cycloalkenones afforded the addition products in moderate selectivity. Among phosphines examined, 5-[(diphenylphosphiao)methyl]-3,3-dimethylpyrrolidin-2- one 5 gave rise to moderate enantioselectivity and high yield. (C) 2000 Elsevier Science Ltd.