1560-96-9Relevant articles and documents
Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step
Tanaka, Katsunori,Motomatsu, Shinya,Koyama, Koichi,Tanaka, Shin-Ichi,Fukase, Koichi
, p. 299 - 302 (2007)
(Figure Presented) An efficient protocol of dehydration was developed under microfluidic conditions. The method was applied to a multikilogram synthesis of pristane, a biologically important natural product, which is now widely used as an adjuvant for monoclonal antibody production.
Iron-catalyzed AlkylAlkyl negishi coupling of organoaluminum reagents
Agata, Ryosuke,Kawamura, Shintaro,Isozaki, Katsuhiro,Nakamura, Masaharu
supporting information, p. 238 - 241 (2019/03/13)
The first iron-catalyzed cross-coupling reaction of alkyl halides with alkylaluminum reagents (alkylalkyl Negishi coupling) is developed using an iron/bisphosphine catalyst system. The reaction shows high functional group tolerance: various primary alkyl halides possessing a non-protected indole, carboxyl, or hydroxy group are coupled with primary alkylaluminum reagents in good yields. Potassium fluoride plays a key role to promote the reaction by generating an aluminate species, which facilitates the transmetalation between the organoaluminum and the iron catalyst.
Process for hydrogenation of carboxylic acids and derivatives to hydrocarbons
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Page/Page column 7-8, (2008/06/13)
A process for hydrogenating a carboxylic acid and/or derivative thereof having a carboxylate group represented by the general formula R1COO-, which process comprises feeding hydrogen and the carboxylic acid and/or derivative thereof to a reactor and maintaining conditions within the reactor such that hydrogen reacts with the carboxylic acid and/or derivative thereof to produce a product stream comprising carbon dioxide, carbon monoxide, methane and hydrocarbons represented by general formulae R1H and R1CH3, characterised in that the molar ratio of R1H : R1CH3 is above a pre-determined value and/or the mole ratio of the sum of carbon dioxide, carbon monoxide and methane to carboxylate groups is above a pre-determined value.