1572922-64-5

Basic information

• Product Name: C₂₀H₁₅Cl₂N₃O₄S
• CAS NO: 1572922-64-5
• Molecular Weight: 464.329
• Mol File: 1572922-64-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₅Cl₂N₃O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₅Cl₂N₃O₄S(1572922-64-5)
• EPA Substance Registry System: C₂₀H₁₅Cl₂N₃O₄S(1572922-64-5)

Safety Data

• Hazardous Substances Data: 1572922-64-5(Hazardous Substances Data)

Upstream product

• 106904-10-3 2-chloro-4-(methylsulphonyl)benzoyl chloride 
• 53250-83-2 2-chloro-4-(methanesulfonyl)benzoic acid 
• 1572922-59-8 C₁₉H₂₀Cl₂N₂O₅S 
• 879614-93-4 tert-butyl 5-amino-2-chlorophenylcarbamate 
• 879614-90-1 C₁₁H₁₃ClN₂O₄ 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 

Relevant articles and documents

Synthesis and biological evaluation of novel benzamide derivatives as potent smoothened antagonists

A series of novel benzamide derivatives were prepared and evaluated using cell-based measurements. Among these compounds, 10f significantly inhibited Hedgehog signaling and showed equivalent or more potency than GDC-0449 in different tests. Furthermore, compound 10f potently inhibited the proliferation of Daoy, a medulloblastoma cell line that is reported to be resistant to GDC-0449, which indicated a promising prospect in the treatment of Hedgehog signaling pathway related cancer in clinical trial.