879614-90-1Relevant articles and documents
Synthesis and biological evaluation of novel benzamide derivatives as potent smoothened antagonists
Wu, Tian-Ming,Wang, Dao-Cai,Xiang, Pu,Zhang, Jian-Nan,Sang, Ya-Xiong,Lin, Hong-Jun,Chen, Jie,Xie, Gang,Song, Hang,Zhao, Ying-Lan,Xie, Yong-Mei
, p. 1426 - 1431 (2014/03/21)
A series of novel benzamide derivatives were prepared and evaluated using cell-based measurements. Among these compounds, 10f significantly inhibited Hedgehog signaling and showed equivalent or more potency than GDC-0449 in different tests. Furthermore, compound 10f potently inhibited the proliferation of Daoy, a medulloblastoma cell line that is reported to be resistant to GDC-0449, which indicated a promising prospect in the treatment of Hedgehog signaling pathway related cancer in clinical trial.