1576-14-3Relevant articles and documents
Edaravone analogue as well as preparation method and application thereof
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Paragraph 0023-0024, (2020/03/16)
Edaravone analogue, preparation method thereof and application, compound according to the following structural formula: In-flight, R1 And R2 The compounds of the present invention are methyl, methoxy, ethyl, isopropyl, tert-butyl or sec-butyl . with GABAA receptor enhancing activity and radical scavenger activity, having neuroprotective action, and compounds of the present invention can be used as a stroke prevention and treatment drug.
A Propofol preparation method
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Paragraph 0027; 0028; 0029; 0030; 0031; 0032; 0033; 0034, (2017/10/28)
The invention provides a preparation method of propofol, which includes following steps: (1) performing Friedel-crafts reaction to p-nitrophenol and isopropanol or 2-halogenated propane under catalysis of an acid to prepare a compound I; (2) performing acylation protection to the compound I to prepare a compound II; (3) performing a reduction reaction to the compound II to prepare a compound III; (4) performing a diazo-reaction to the compound III to prepare a compound IV; and (5) under a weak reducing agent condition, performing a decomposition reaction to the compound IV and meanwhile carrying out hydrolysis under an alkaline condition to obtain the propofol V. The raw materials of the preparation method are easy to obtain. The preparation method is simple in process and is high in yield.
A convenient method for synthesizing modified 4-nitrophenols
Nakaike, Yumi,Kamijo, Yoshio,Mori, Satoshi,Tamura, Mina,Nishiwaki, Nagatoshi,Ariga, Masahiro
, p. 10169 - 10171 (2007/10/03)
β-Nitroenamine having a formyl group behaves as the synthetic equivalent of unstable nitromalonaldehyde upon treatment with ketones under basic conditions and leads to 2,6-disubstituted 4-nitrophenols. The present method is safer than the conventional one using sodium nitromalonaldehyde and enables the preparation of hitherto unknown nitrophenols.