2078-54-8 Usage
Description
Propofol, also known by its brand names Diprivan, Disoprivan, Disprofol, and Rapinovet, is an injectable, short-acting general anesthetic with a low incidence of side effects. It is a light yellow liquid that is only slightly soluble in water, with an octanol/water partition coefficient of 6,761:1. Propofol is formulated as an oil-in-water emulsion, with the fat component consisting of soybean oil, glycerol, and egg lecithin. The pKa of the propanol hydroxyl is 11, and the injectable emulsion has a pH of 7 to 8.5. Formulations may contain disodium ethylenediaminetetraacetic acid (EDTA) or sodium metabisulfite to retard the growth of microorganisms.
Uses
Used in Veterinary Medicine:
Propofol is used as an anesthetic for veterinary medicine, providing a safe and effective means of inducing and maintaining anesthesia or sedation in animals.
Used in Human Medicine:
Propofol is used as an anesthetic for the induction and maintenance of anesthesia or sedation in human patients. Its short-acting nature and low side effect profile make it a preferred choice for various medical procedures.
Used in Pharmaceutical Formulations:
2,6-DIPP, the active ingredient for intravenous anesthetic formulations, is also used as an intermediate for polymers. This highlights the versatility of Propofol and its derivatives in the pharmaceutical and chemical industries.
Originator
ICI (United Kingdom)
World Health Organization (WHO)
Propofol, a short acting injectable anaesthetic, was introduced in
1987. In April 1992, the Norwegian Medicines Control Board reported that
prolonged use of propofol had been associated with two fatalities in children
characterized by metabolic acidosis, liver enlargement, and cerebral oedema. The
UK Committee on the Safety of Medicines has received 5 reports of deaths
occurring in children who had received propofol while in intensive care.
Biological Functions
Propofol (Diprivan) is rapidly acting, has a short recovery
time, and possesses antiemetic properties. A rapid
onset of anesthesia (50 seconds) is achieved, and if no
other drug is administered, recovery will take place in 4
to 8 minutes.The recovery is attributed to redistribution
of the drug and rapid metabolism to glucuronide and
sulfate conjugates by the liver and extrahepatic tissues,
such as intestine and kidney.
Rapid recovery and its antiemetic properties make
propofol anesthesia very popular as an induction agent
for outpatient anesthesia. Propofol can also be used to
supplement inhalational anesthesia in longer procedures.
Both continuous infusion of propofol for conscious
sedation and with opioids for the maintenance of
anesthesia for cardiac surgery are acceptable techniques.
Synthesis Reference(s)
The Journal of Organic Chemistry, 21, p. 712, 1956 DOI: 10.1021/jo01112a621
Biological Activity
Intravenous general anesthetic and hypnotic with a mode of action which includes potentiation of GABA-mediated inhibitory synaptic transmission, direct activation of the GABA A receptor and inhibition of glutamate receptor mediated excitatory synaptic transmission. Also potentiates P2X 4 receptor-mediated currents in P2X 4 -HEK293 cells.
Pharmacology
Propofol is primarily a hypnotic drug with substantial
cardiorespiratory depressant actions and with no ability
to produce neuromuscular blockade. While propofol
lacks analgesic properties, its use permits lower doses of
opioids. Likewise, less propofol is required for adequate
hypnosis when it is administered with opioids.Thus, it is
said that propofol and opioids interact synergistically.
Clinical Use
Generic formulations of propofol may contain sodiummetabisulfite as the antimicrobial agent, and patients allergicto sulfites, especially asthmatic patients, should avoid thisformulation. Aseptic technique must be followed and unusedportions of the drug must be discarded according to the manufacturer’s instructions to prevent microbial contaminationand possible sepsis.
Side effects
The dose of propofol should be reduced in older patients;
however, it does have a relatively linear dose–
response characteristic, and patients generally can be safely titrated. The pain on injection, especially when
small veins are used, can be considerably reduced if lidocaine
20 mg is administered first.
Anesthesia induction with propofol causes a significant
reduction in blood pressure that is proportional to
the severity of cardiovascular disease or the volume status
of the patient, or both. However, even in healthy patients
a significant reduction in systolic and mean arterial
blood pressure occurs. The reduction in pressure
appears to be associated with vasodilation and myocardial
depression. Although propofol decreases systemic
vascular resistance, reflex tachycardia is not observed.
This is in contrast to the actions of thiopental.
The heart rate stabilization produced by propofol relative
to other agents is likely the result of either resetting
or inhibiting the baroreflex, thus reducing the tachycardic
response to hypotension.
Since propofol does not depress the hemodynamic
response to laryngoscopy and intubation, its use may
permit wide swings in blood pressure at the time of induction
of anesthesia. Propofol should be used with utmost
caution in patients with cardiac disease.
Safety Profile
Poison by intravenous
and intraperitoneal routes. Experimental
reproductive effects. Combustible when
exposed to heat or flame; can react with
oxidizing materials. To fight fire, use foam,
CO2, dry chemical. When heated to
decomposition it emits acrid smoke and
fumes. See also PHENOL
Veterinary Drugs and Treatments
In appropriate patients, propofol may be useful as an induction
agent (especially before endotracheal intubation or an inhalant anesthetic),
and as an anesthetic for outpatient diagnostic or minor
procedures (e.g., laceration repair, radiologic procedures, minor
dentistry, minor biopsies, endoscopy, etc.).
Propofol is used as a treatment for refractory status epilepticus,
as it tends to cause less cardiovascular depression and recoveries can
be smoother than with pentobarbital. Propofol may be of particular
usefulness for use in Greyhounds and in patients with preexisting
cardiac dysrhythmias. At low dosages, propofol is being investigated
as an appetite stimulant in dogs.
Propofol may be safely used in animals with liver or renal disease
and mild to moderate cardiac disease.
In dogs, propofol’s labeled indications are: 1) for induction of
anesthesia; 2) for maintenance of anesthesia for up to 20 minutes;
3) for induction of general anesthesia where maintenance is provided
by inhalant anesthetics.
Check Digit Verification of cas no
The CAS Registry Mumber 2078-54-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,7 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2078-54:
(6*2)+(5*0)+(4*7)+(3*8)+(2*5)+(1*4)=78
78 % 10 = 8
So 2078-54-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
2078-54-8Relevant articles and documents
Non-catalytic and selective alkylation of phenol with propan-2-ol in supercritical water
Sato,Sekiguchi,Adschiri,Arai
, p. 1566 - 1567 (2001)
Phenol can be alkylated with propan-2-ol without catalyst in supercritical water at 673 K with mainly ortho substituted alkylphenols being obtained and alkylation reaction rate increasing with increasing water density.
Synthesis and catalytic performance of HMCM-49/MCM-41 composite molecular sieve for alkylation of phenol with isopropanol
Wei, Liguo,Wang, Dong,Dong, Yongli,Song, Weina,Liu, Xiaoxu,Song, Kunyao
, p. 2061 - 2066 (2017)
HMCM-49/MCM-41 composite molecular sieve was synthesized with hydrothermal method. The physicochemical properties of the composite were characterized by using XRD, FT-IR, SEM, N2 isothermal adsorption-desorption and NH3-TPD. Results of different characterizations indicated that the synthesized composite molecular sieve possessed the characteristics of both HMCM-49 and MCM-41. XRD and N2 isothermal adsorption-desorption revealed that it has both micropores and mesopores, a larger surface area than that of HMCM-49, NH3-TPD and pyridine adsorbed FT-IR revealed that the strong acidic sites that caused side reaction in HMCM-49 are deactivated in the composite molecular sieve of HMCM-49/MCM-41. When applied to the alkylation of phenol with isopropanol, the HMCM-49/MCM-41 composite molecular sieve exhibit an enhanced catalytic performance with significant enhancement in p-isopropylphenol and o-isopropylphenol selectivity, which can be ascribed to the composite characteristics of HMCM-49 and MCM-41. This kind of material will has widely industrial application in preparation of alkyl-phenol.
A mild and practical method for deprotection of aryl methyl/benzyl/allyl ethers with HPPh2andtBuOK
Pan, Wenjing,Li, Chenchen,Zhu, Haoyin,Li, Fangfang,Li, Tao,Zhao, Wanxiang
, p. 7633 - 7640 (2021/09/22)
A general method for the demethylation, debenzylation, and deallylation of aryl ethers using HPPh2andtBuOK is reported. The reaction features mild and metal-free reaction conditions, broad substrate scope, good functional group compatibility, and high chemical selectivity towards aryl ethers over aliphatic structures. Notably, this approach is competent to selectively deprotect the allyl or benzyl group, making it a general and practical method in organic synthesis.
Continuous flow synthesis of propofol
Jubault, Philippe,Legros, Julien,Mougeot, Romain,Poisson, Thomas
supporting information, (2021/12/02)
Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol— also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel–Crafts alkylation followed by a decarboxylation step, both under continuous flow.
PROCESS FOR THE PREPARATION OF PROPOFOL
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Page/Page column 11-12, (2021/10/02)
The present provides a simple, convenient and time-efficient process for the preparation of propofol. Particularly, the present invention provides an improved process for the preparation of propofol using a heterocyclic base for the decarboxylation reaction. The present invention provides a time-efficient process for the preparation of propofol with high yield and purity.