15805-73-9 Usage
Description
Vinyl Carbamate is a white crystalline solid with potent promutagenic properties. It is known to induce mutations in Salmonella typhimurium strains TA 1535 and TA 100 when in the presence of reduced nicotinamide adenine dinucleotide phosphate-fortified rat or mouse liver mitochondrial supernatant fractions.
Uses
1. Used in Research Applications:
Vinyl Carbamate is used as a research chemical for studying its mutagenic effects on various organisms, particularly Salmonella typhimurium strains TA 1535 and TA 100. This application helps scientists understand the mechanisms of mutagenesis and the potential risks associated with exposure to Vinyl Carbamate.
2. Used in Pharmaceutical Industry:
Vinyl Carbamate is used as a starting material for the synthesis of various pharmaceutical compounds. Its mutagenic properties make it a valuable tool in the development of new drugs and therapies.
3. Used in Environmental Monitoring:
Vinyl Carbamate can be used as an indicator in environmental monitoring to detect the presence of specific contaminants or to assess the mutagenic potential of environmental samples.
4. Used in Toxicology Studies:
Vinyl Carbamate is used as a test compound in toxicology studies to evaluate the potential health risks and effects of exposure to mutagenic substances. This helps in the development of safety guidelines and regulations for handling and disposing of such chemicals.
Air & Water Reactions
Moderately water soluble.
Reactivity Profile
Vinyl Carbamate is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates. Vinyl Carbamate is incompatible with strong oxidizing agents, strong acids and strong bases. .
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition Vinyl Carbamate emits toxic fumes of carbon monoxide, carbon dioxide and oxides of nitrogen.
Fire Hazard
Flash point data for Vinyl Carbamate are not available; however, Vinyl Carbamate is probably combustible.
Safety Profile
Poison by
intraperitoneal route. Questionable
carcinogen with experimental neoplastigenic
data. Human mutation data reported. When
heated to decomposition it emits toxic
fumes of NOx. See also ESTERS and
CARBAMATES.
Check Digit Verification of cas no
The CAS Registry Mumber 15805-73-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,8,0 and 5 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 15805-73:
(7*1)+(6*5)+(5*8)+(4*0)+(3*5)+(2*7)+(1*3)=109
109 % 10 = 9
So 15805-73-9 is a valid CAS Registry Number.
InChI:InChI=1/C3H5NO2/c1-2-6-3(4)5/h2H,1H2,(H2,4,5)
15805-73-9Relevant articles and documents
Lysosomal Reacidification Ameliorates Vinyl Carbamate-Induced Toxicity and Disruption on Lysosomal pH
Chen, Wei,Cui, Sunliang,Hu, Dongwen,Li, Yuting,Qi, Jifeng
, p. 8951 - 8961 (2020/09/16)
Ethyl carbamate (EC) is a carcinogen toxicant, commonly found in fermented foods and beverages. The carcinogenic and toxic possibility of EC is thought to be related to its metabolite vinyl carbamate (VC). However, we found interesting mechanisms underlying VC-induced toxicity in this study, which were greatly different from EC. We first conducted a simple synthesis procedure for VC and found that VC possessed higher toxicity but failed to regulate levels of reactive oxygen species, glutathione, and autophagy. Notably, VC treatment resulted in upregulation of lysosomal pH, which was responsible for its cytotoxicity. Cyclic adenosine monophosphate (cAMP) pretreatment could enhance restoration of lysosomal acidity and ameliorate VC-induced damage. Inhibition of protein kinase A and cystic fibrosis transmembrane conductance regulator can block cAMP-induced cytoprotection. Together, our results provided the evidence for novel mechanisms of toxicity and possible protection method under VC exposure, which might give new perspectives on the study of EC-induced toxicity.
Hepatitis C inhibitor tri-peptides
-
, (2008/06/13)
Disclosed herein are compounds of formula (1): wherein Ris hydroxy or NHSO2Rwherein Ris (C1-8)alkyl, (C3-7)cycloalkyl or {(C1-6)alkyl-(C3-7)cycloalkyl}, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O-(C1-6)alkyl, amido, amino or phenyl, or Ris C6 or C10 aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O-(C1-6) alkyl, amido, amino or phenyl; Ris (C4-6)cycloalkyl; Ris t-btuyl or (C5-6) cycloalkyl and Ris (C4-6)cycloalkyl; or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of HCV NS3 protease.
Vinyl chloroformates and preparation
-
, (2008/06/13)
Vinyl chloroformates are described of formula STR1 in which: R1 =R2 =Cl, Br or a saturated 1-4 carbon atom alkyl or together they form a cycloaliphatic ring of 4-8 carbon atoms; R3 =H when R1 or R2 =a