1582-24-7Relevant articles and documents
Visible-Light-Induced Selective Defluoroborylation of Polyfluoroarenes, gem-Difluoroalkenes, and Trifluoromethylalkenes
Jiang, Heming,Leng, Jing,Ong, Han-Wee,Wu, Jie,Xu, Wengang
, p. 4009 - 4016 (2020)
Fluorinated organoboranes serve as versatile synthetic precursors for the preparation of value-added fluorinated organic compounds. Recent progress has been mainly focused on the transition-metal catalyzed defluoroborylation. Herein, we report a photocatalytic defluoroborylation platform through direct B?H activation of N-heterocyclic carbene boranes, through the synergistic merger of a photoredox catalyst and a hydrogen atom transfer catalyst. This atom-economic and operationally simple protocol has enabled defluoroborylation of an extremely broad scope of multifluorinated substrates including polyfluoroarenes, gem-difluoroalkenes, and trifluoromethylalkenes in a highly selective fashion. Intriguingly, the defluoroborylation protocol can be transition-metal free, and the regioselectivity obtained is complementary to the reported transition-metal-catalysis in many cases.
The preparation of pentafluorophenyldihaloboranes from pentafluorophenylmercurials C6F5HgR and BX3: the dramatic dependence of the reaction direction on the ligand R
Bardin, Vadim V.,Adonin, Nicolay Yu.
, p. 1523 - 1531 (2019/07/22)
Abstract: In search of convenient preparations of C6F5BX2 (X = Cl, Br), reactions of C6F5HgR (R = C6F5, C6H5, C2H5, Br and Cl) with BX3 were studied. Under the action of BCl3 the order of the C–Hg bond cleavage is C6F5Hg–C6H5 > C6F5–HgC2H5 > C6F5–HgC6F5 >> C6F5–HgCl. With more reactive BBr3 the sequence is C6F5Hg–C6H5 > C6F5–HgC2H5 ~ C6F5Hg–C2H5 > C6F5–HgC6F5 ≥ C6F5–HgBr. During the study we found the simple way to alkyldibromoboranes which is presented by the preparation of C2H5BBr2 from C2H5HgBr and BBr3. It is the second example of synthesis of alkylmercury derivative in an addition to the earlier reported formation of cyclopropylmercurials from di(cyclopropyl)mercury and BX3. Graphic abstract: [Figure not available: see fulltext.].
Preparation method of pentafluorophenol
-
Paragraph 0100-0101; 0105; 0109; 0113; 0117, (2017/08/29)
The invention relates to the field of organic synthesis and in particular relates to a preparation method of pentafluorophenol. The structural formula of pentafluorophenol is as shown in a formula I. The preparation method specifically comprises the following steps of: (1) decarboxylic reaction; (2) Grignard reaction; and (3) oxidizing reaction. According to the preparation method of pentafluorophenol, raw materials are easily available and are low in cost, the production cost is low, the waste of bromine resources is avoided, and adverse effects on the environment are reduced; meanwhile, the preparation method of pentafluorophenol is mild in reaction condition, high in process safety, few in product impurity, easy in extraction and purification and stable in quality; and the content of pentafluorophenol obtained by refining is greater than 99%, so that the preparation method is completely suitable for large-scale industrial production.