15898-43-8

Basic information

• Product Name: 4-ACETAMIDOBENZENESULFINIC ACID SODIUM SALT
• Synonyms: p-AcetaMidobenzenesulphinic Acid SodiuM Salt;p-Sulfinoacetanilide SodiuM Salt;SodiuM 4-(AcetylaMino)benzenesulf;4-ACETAMIDOBENZENESULFINIC ACID SODIUM SALT;4-ACETAMIDOBENZENESULFINIC ACID SODIUM SALT DIHYDRATE;SODIUM 4-ACETAMIDOBENZENESULFINATE DIHYDRATE;P-ACETYLAMINO-BENZENESULFINIC ACID SODIUM SALT;Acetamidobenzenesulfinicacidsodiumsalt
• CAS NO: 15898-43-8
• Molecular Formula: C₈H₈NO₃S*Na
• Molecular Weight: 221.21
• Mol File: 15898-43-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: >270 °C
• Appearance: /
• Storage Temp.: Hygroscopic, Room Temperature, under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly),Water(Slightly)
• Water Solubility: almost transparency
• Stability: Very Hygroscopic
• CAS DataBase Reference: 4-ACETAMIDOBENZENESULFINIC ACID SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETAMIDOBENZENESULFINIC ACID SODIUM SALT(15898-43-8)
• EPA Substance Registry System: 4-ACETAMIDOBENZENESULFINIC ACID SODIUM SALT(15898-43-8)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 15898-43-8(Hazardous Substances Data)

Usage

Description

4-Acetamidobenzenesulfinic Acid Sodium Salt, also known as 4-AMS, is an organic compound with the chemical formula C7H7NO2SNa. It is a white solid and serves as an important intermediate in the synthesis of various organic compounds, particularly in the production of cyanine dyes.

Uses

Used in Dye Industry:
4-Acetamidobenzenesulfinic Acid Sodium Salt is used as a key intermediate in the synthesis of cyanine dyes for the dye industry. These dyes are widely used in various applications, including biological imaging, solar cells, and other optical devices, due to their unique photophysical properties and high absorption coefficients.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, 4-Acetamidobenzenesulfinic Acid Sodium Salt may also have potential applications in the pharmaceutical industry as a precursor for the synthesis of various pharmaceutical compounds. Its reactivity and functional groups can be utilized to create a range of therapeutic agents.
Used in Chemical Research:
4-Acetamidobenzenesulfinic Acid Sodium Salt can be used as a research compound in the field of organic chemistry. Its unique structure and properties make it a valuable tool for studying various chemical reactions and mechanisms, contributing to the advancement of chemical knowledge and the development of new synthetic methods.

Upstream product

• 103-84-4 Acetanilid 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 3660-40-0 S-phenyl 4-acetamidobenzenesulfonothioate 

Downstream Products

• 100862-20-2 acetic acid-[4-(2-diethylamino-ethanesulfonyl)-anilide] 
• 52183-58-1 1,2-Di(4-acetamidophenylsulphono)ethane 
• 130188-92-0 acetic acid-{4-[2-(4-bromo-phenyl)-2-oxo-ethanesulfonyl]-anilide} 
• 41142-13-6 (4-Acetylamino-benzenesulfonyl)-methoxycarbonylamino-acetic acid 
• 40003-38-1 2-(4-acetylamino-benzenesulfonyl)-4-methyl-thiazole-5-carboxylic acid anilide 
• 125743-97-7 4'-acetamino-2-methylamino-4-nitro-diphenylsulfone 
• 91088-10-7 acetic acid-[4-(2-cyano-ethanesulfonyl)-anilide] 
• 1775-37-7 N-[4-(4-Nitro-benzenesulfonyl)-phenyl]-acetamide 
• 128646-71-9 4-amino-2'-nitro-4'-sulfodiphenyl sulfone 
• 4284-52-0 3-(4-acetamidobenzenesulfonyl) acrylonitrile 
• 100867-36-5 N-(4-((2,5-dihydroxyphenyl)sulfonyl)phenyl)acetamide 
• 102028-78-4 acetic acid-[4-(1,4-dihydroxy-naphthalene-2-sulfonyl)-anilide] 
• 2719-21-3 4-(N-acetylamino)acetophenone 

Relevant articles and documents

Aromatic sulfinic acid compound and preparation method thereof

The invention relates to a preparation method of an aromatic sulfinic acid compound, which comprises the following steps: dissolving an aromatic compound in a liquid coordination complex, and introducing sulfur dioxide to carry out Friedel-Crafts acylation reaction under the protection of inert gas to prepare the aromatic sulfinic acid compound. According to the preparation method, the liquid coordination complex prepared from the metal and the organic ligand is used as the catalyst and the solvent, other organic solvents do not need to be additionally added, the reaction rate is high, the yield is high, the product purity is high and can reach 97% on the whole, aftertreatment is simple, and the preparation method is suitable for large-scale production.

Enhancing the Potential of Miniature-Scale DNA-Compatible Radical Reactions via an Electron Donor-Acceptor Complex and a Reversible Adsorption to Solid Support Strategy

DNA-encoded library (DEL) technology is a powerful tool in the discovery of bioactive probe molecules and drug leads. Mostly, the success in DEL technology stems from the molecular diversity of the chemical libraries. However, the construction of DELs has been restricted by the idiosyncratic needs and the required low concentration (～1 mM or less) of the library intermediate. Here, we report visible-light-promoted on-DNA radical coupling reactions via an electron donor-acceptor (EDA) complex and a reversible adsorption to solid support (RASS) strategy. This protocol provides a unique solution to the challenges of increasing the reactivity of highly diluted DNA substrates and reducing the residues of heavy metals from photocatalysts. A series of on-DNA indole sulfone and selenide derivatives were obtained with good to quantitative conversions. It is anticipated that these mild-condition on-DNA radical reactions will significantly improve the chemical diversity of DELs and find widespread utility to DEL construction.

Metal-Free Chemoselective Reaction of Sulfoxonium Ylides and Thiosulfonates: Diverse Synthesis of 1,4-Diketones, Aryl Sulfursulfoxonium Ylides, and β-Keto Thiosulfones Derivatives

A diverse chemoselective insertion reaction of sulfoxonium ylides and thiosulfonates under transition-metal-free conditions is developed, which successfully affords 1,4-diketone compounds, arylthiosulfoxide-ylides, and β-keto thiosulfones, respectively. The nucleophilic addition of two molecular sulfoxonium ylides to construct sulfone-substituted 1,4-dione compounds is the highlight of this work.