159000-75-6Relevant articles and documents
Preparation of Some Novel S-Nitroso Compounds as Potential Slow-release Agents of Nitric Oxide in vivo
Moynihan, Humphrey A.,Roberts, Stanley M.
, p. 797 - 806 (2007/10/02)
The optimum conditions for the preparation of N-acetyl-S-nitrosopenicillamine (SNAP) 3 were determined and applied to the synthesis of the corresponding N-formyl compound 7.The nitrosation of penicillamine dipeptides was investigated and bis-thionitroso compounds 13, 18, 26 and 27 were isolated.S,S'-Dinitroso dithiol 13 showed biological activity akin to that of glyceryl trinitrate in decreasing systemic arterial blood pressure in anaesthetized rats and rabbits.Concomitant inhibition of collagen- or ADP-induced platelet aggregation was observed.