1598408-85-5

Basic information

• Product Name: C₂₁H₁₈N₂O₃
• Synonyms: C₂₁H₁₈N₂O₃
• CAS NO: 1598408-85-5
• Molecular Weight: 346.386
• Mol File: 1598408-85-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₈N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₈N₂O₃(1598408-85-5)
• EPA Substance Registry System: C₂₁H₁₈N₂O₃(1598408-85-5)

Safety Data

• Hazardous Substances Data: 1598408-85-5(Hazardous Substances Data)

Upstream product

• 729-01-1 4'-nitrobiphenyl-3-carboxylic acid 
• 25487-66-5 3-Carboxyphenylboronic acid 
• 586-78-7 para-nitrophenyl bromide 
• 618-36-0 rac-methylbenzylamine 

Downstream Products

• 1598408-66-2 C₂₁H₂₀N₂O 
• 1598408-47-9 1-(4-(3-(1-phenylethylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 

Relevant articles and documents

Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents

A novel series of diaryl ureas containing different linker groups were designed and synthesized. Their in vitro antitumor activity against MX-1, A375, HepG2, Ketr3 and HT-29 was evaluated using the standard MTT assay. Compounds having a rigid linker group such as vinyl, ethynyl and phenyl showed significant inhibitory activity against a variety of cancer cell lines. Specifically, compound 23 with a phenyl linker group demonstrated broad-spectrum antitumor activity with IC50 values of 5.17-6.46 μM against five tested tumor cell lines. Compound 23 is more potent than reference drug sorafenib (8.27-15.2 μM), representing a promising lead for further optimization.