729-01-1

Basic information

• Product Name: 4'-Nitro-3-biphenylcarboxylic acid
• Synonyms: 4'-Nitro-3-biphenylcarboxylic acid;3-(4-Nitrophenyl)benzoic acid;4-Nitrobiphenyl-3-carboxylic acid;[1,1'-Biphenyl]-3-carboxylicacid, 4'-nitro-
• CAS NO: 729-01-1
• Molecular Formula: C₁₃H₉NO₄
• Molecular Weight: 243.21
• Mol File: 729-01-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4'-Nitro-3-biphenylcarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Nitro-3-biphenylcarboxylic acid(729-01-1)
• EPA Substance Registry System: 4'-Nitro-3-biphenylcarboxylic acid(729-01-1)

Safety Data

• Hazardous Substances Data: 729-01-1(Hazardous Substances Data)

Usage

General Description

4’-Nitro-3-biphenylcarboxylic acid is a chemical compound with the molecular formula C13H9NO4. It is a derivative of biphenyl and carboxylic acid, with a nitro group attached to the 4’ position of the biphenyl ring. 4'-Nitro-3-biphenylcarboxylic acid is commonly used in the synthesis of other organic compounds and pharmaceutical products. It is also known for its potential use as a detection agent for alkali and alkaline earth metal ions. Additionally, it has been studied for its potential use in the design of new materials and as a catalyst in organic reactions. The compound's properties and potential applications make it a subject of interest in the fields of chemistry and materials science.

Upstream product

• 17933-03-8 m-tolylboronic acid 
• 107558-26-9 methyl 4'-nitro-[1,1'-biphenyl]-3-carboxylate 
• 25487-66-5 3-Carboxyphenylboronic acid 
• 586-78-7 para-nitrophenyl bromide 
• 71-43-2 benzene 
• 87360-24-5 3-amino-benzoic acid methyl ester hydrochloride 
• 16606-00-1 methyl 3-phenylbenzoate 
• 351-36-0 N-acetyl-3-trifluoromethylbenzenamine 
• 366-04-1 3-(trifluoromethyl)biphenyl 
• 98-07-7 Benzotrichlorid 
• 952-21-6 4-nitro-3'-methylbiphenyl 
• 346-99-6 4-nitro-3'-(trifluoromethyl)-1,1'-biphenyl 
• 716-76-7 3-phenylbenzoic acid 

Downstream Products

• 172542-50-6 4--3-<(triphenylmethyl)thio>propyl>amino>-3'-(tert-butoxycarbonyl)biphenyl 
• 1598408-47-9 1-(4-(3-(1-phenylethylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 
• 620963-03-3 1-(4-(3-(Methylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 
• 1598408-85-5 C₂₁H₁₈N₂O₃ 
• 1598408-84-4 C₁₄H₁₂N₂O₃ 
• 1598408-66-2 C₂₁H₂₀N₂O 
• 1335041-46-7 C₁₄H₁₄N₂O 
• 1360630-32-5 methyl 4'-(6-carbamoyl-2-naphthamido)biphenyl-3-carboxylate 
• 1360630-30-3 methyl 4'-(2-naphthamido)biphenyl-3-carboxylate 
• 400747-22-0 methyl 4' amino-[1,1'-biphenyl]-3-carboxylate 
• 1360630-56-3 4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-3-carboxamide 
• 1360630-55-2 methyl 4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-3-carboxylate 
• 1360630-51-8 methyl 4'-(naphthalene-2-sulfonamido)biphenyl-3-carboxylate 
• 1360630-50-7 methyl 4'-(6-amino-2-naphthamido)biphenyl-3-carboxylate 

Relevant articles and documents

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

We report on the virtual screening, synthesis, and biological evaluation of new furan derivatives targeting Mycobacterium tuberculosis salicylate synthase (MbtI). A receptor-based virtual screening procedure was applied to screen the Enamine database, identifying two compounds, I and III, endowed with a good enzyme inhibitory activity. Considering the most active compound I as starting point for the development of novel MbtI inhibitors, we obtained new derivatives based on the furan scaffold. Among the SAR performed on this class, compound 1a emerged as the most potent MbtI inhibitor reported to date (Ki = 5.3 μM). Moreover, compound 1a showed a promising antimycobacterial activity (MIC99 = 156 μM), which is conceivably related to mycobactin biosynthesis inhibition.

Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA)

Recent drug discovery programs targeting urokinase plasminogen activator (uPA) have resulted in nonpeptidic inhibitors consisting of amidine or guanidine functional groups attached to aromatic or heteroaromatic scaffolds. There is a general problem of poor oral bioavailability of these charged inhibitors. In this paper, we report the synthesis and evaluation of a series of naphthamide and naphthalene sulfonamides as uPA inhibitors containing non-basic groups as substitute for amidine or guanidine groups.

AMINO ACIDS

Compounds of formula (I): Z’ -CO-A-B-NH-Z (I) wherein: Z is H or an amino protecting group; Z’ is OH, a protected or activated hydroxyl group or C1; A is an optionally substituted C5-6 arylene group; and B is an optionally substituted C5-6 arylene group.