160823-59-6Relevant articles and documents
An asymmetric synthesis of (-)-deoxypodophyllotoxin
Bogucki,Charlton
, p. 588 - 593 (2007/10/02)
A Diels-Alder cycloaddition between the fumarate of methyl (S)-mandelate (22) and α-hydroxy-α-aryl-o-quinodimethane 21 produces an endo cycloadduct (23) in 58% yield. The preparation of the precursor to o-quinodimethane 21 and the conversion of cycloadduct 23 to optically pure (-)-deoxypodophyllotoxin (1) is described.