1621999-28-7

Basic information

• Product Name: (S)-5-(3,3-diphenylallyl)-2,2-dimethyltetrahydrofuran
• CAS NO: 1621999-28-7
• Molecular Weight: 292.421
• Mol File: 1621999-28-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-5-(3,3-diphenylallyl)-2,2-dimethyltetrahydrofuran(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-(3,3-diphenylallyl)-2,2-dimethyltetrahydrofuran(1621999-28-7)
• EPA Substance Registry System: (S)-5-(3,3-diphenylallyl)-2,2-dimethyltetrahydrofuran(1621999-28-7)

Safety Data

• Hazardous Substances Data: 1621999-28-7(Hazardous Substances Data)

Upstream product

• 530-48-3 1,1-Diphenylethylene 
• 16744-89-1 2-methylhex-5-en-2-ol 

Relevant articles and documents

Enantioselective copper-catalyzed carboetherification of unactivated alkenes

Chiral saturated oxygen heterocycles are important components of bioactive compounds. Cyclization of alcohols onto pendant alkenes is a direct route to their synthesis, but few catalytic enantioselective methods enabling cyclization onto unactivated alkenes exist. Herein reported is a highly efficient copper-catalyzed cyclization of γ-unsaturated pentenols which terminates in C-C bond formation, a net alkene carboetherification. Both intra- and intermolecular C-C bond formations are demonstrated, thus yielding functionalized chiral tetrahydrofurans as well as fused-ring and bridged-ring oxabicyclic products. Transition-state calculations support a cis-oxycupration stereochemistry-determining step.