1634-62-4Relevant articles and documents
Method for asymmetrically synthesizing Triptonide and Triptolide
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Paragraph 0071-0078, (2021/08/25)
The invention discloses a method for asymmetrically synthesizing triptonide and triptolide, the method comprises the following steps: starting from (-)-Taniguchi lactone, developing a framework structure of the triptolide through alkylation reaction, transition metal catalytic hydrogen atom transfer reaction and aldol type ring closing reaction, further completing total synthesis of the triptonide through oxidation reaction, and converting the triptonide into the triptolide through a known reduction reaction. The reaction operation in the synthesis is simple, the method can be widely popularized and used, and a foundation is laid for further structure-function relationship research and structure optimization of the triptolide and the triptolide.