645-13-6 Usage
Description
p-Isopropylacetophenone has an odor reminiscent of orris and
basil. It has a warm, spicy flavor. May be synthesized by condensing cymene with acetyl chloride in the presence of AlCl3; also
from benzol, acetyl chloride, and isopropyl chloride via Friedel Crafts.
Chemical Properties
Different sources of media describe the Chemical Properties of 645-13-6 differently. You can refer to the following data:
1. p-Isopropylacetophenone has a spicy, woody, herbaceous odor reminiscent of orris and basil. It has a warm, spicy flavor
2. clear almost colorless to yellow liquid
Occurrence
Reported found in oil of lavandin, starfruit and dried bonito
Uses
4'-Isopropylacetophenone is used as perfuming agents. It is also used as flavoring and fragrance agent. Indenes are yielded from the derivatives if this compound in one step synthesis using a heterogeneous catalyst.
Preparation
By condensing cymene with acetyl chloride in the presence of AlCl3; also from benzol, acetyl chloride and isopropyl
chloride via Friedel–Craft
Check Digit Verification of cas no
The CAS Registry Mumber 645-13-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,4 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 645-13:
(5*6)+(4*4)+(3*5)+(2*1)+(1*3)=66
66 % 10 = 6
So 645-13-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H14O/c1-8(2)10-4-6-11(7-5-10)9(3)12/h4-8H,1-3H3
645-13-6Relevant articles and documents
-
Nightingale et al.
, p. 244,246 (1953)
-
Aromatization as an Impetus to Harness Ketones for Metallaphotoredox-Catalyzed Benzoylation/Benzylation of (Hetero)arenes
Chen, Ting-Wei,Cheng, Cheng-Ku,Chiu, Cheng-Chau,Huang, Pin-Gong,Lee, Shao-Chi,Lee, Yi-Hsin,Li, Li-Yun,Liao, Hsuan-Hung,Lin, Heng-Bo,Tsai, Zong-Nan,Tsao, Yong-Ting,Yang, Chung-Hsin
supporting information, (2022/01/04)
Herein we report ketones as feedstock materials in radical cross-coupling reactions under Ni/photoredox dual catalysis. In this approach, simple condensation first converts ketones into prearomatic intermediates that then act as activated radical sources for cross-coupling with aryl halides. Our strategy enables the direct benzylation/benzoylation of (hetero)arenes under mild reaction conditions with high functional group tolerance.
Site-Specific Oxidation of (sp3)C-C(sp3)/H Bonds by NaNO2/HCl
Zhao, Jianyou,Shen, Tong,Sun, Zhihui,Wang, Nengyong,Yang, Le,Wu, Jintao,You, Huichao,Liu, Zhong-Quan
, p. 4057 - 4061 (2021/05/26)
A site-specific oxidation of (sp3)C-C(sp3) and (sp3)C-H bonds in aryl alkanes by the use of NaNO2/HCl was explored. The method is chemical-oxidant-free, transition-metal-free, uses water as the solvent, and proceeds under mild conditions, making it valuable and attractive to synthetic organic chemistry.