1641-36-7Relevant articles and documents
Drug specific, tuning of an ionic liquid's hydrophilic-lipophilic balance to improve water solubility of poorly soluble active pharmaceutical ingredients
McCrary, Parker D.,Beasley, Preston A.,Gurau, Gabriela,Narita, Asako,Barber, Patrick S.,Cojocaru, O. Andreea,Rogers, Robin D.
, p. 2196 - 2202 (2013)
Amphotericin B and itraconazole were used to demonstrate that ionic liquids can be designed or chosen to provide tunable hydrophilicity in one ion and lipophilicity in the other allowing one to match the structural requirements needed to solubilize poorly water soluble active pharmaceutical ingredients. These liquid, amphiphilic excipients could be used as both drug delivery systems and solubilization agents to improve the aqueous solubility of many drugs. The solubility in deionized water, simulated gastric fluid, simulated intestinal fluid, and phosphate buffer solution was greatly improved over current methods for drug delivery by utilizing designed ionic liquids as excipients.
Thermodynamic Properties and Intermolecular Interactions of a Series of N-Butylammonium Carboxylate Ionic Liquids
Wei, Ying,Xu, Tongtong,Zhang, Xinyuan,Di, Yang,Zhang, Qingguo
, p. 4475 - 4483 (2018)
A series of new N-butylammonium carboxylate ionic liquids (N-butylammonium formate, N-butylammonium acetate, N-butylammonium propionate, and N-butylammonium butyrate) were synthesized by a one-step method and characterized. The thermodynamic properties such as surface tension, density, electrical conductivity, and dynamic viscosity of the ILs were measured as functions of temperature. Important parameters such as molecular volume, crystal energy, thermal expansion coefficient, standard molar entropy, and the surface properties are estimated by the empirical equations. The Vogel-Fulcher-Tamman (VFT) equation is used to explore the dependence of electrical conductivities and dynamic viscosities on temperature. The relationship between the molar conductivity and the fluidity of the ILs was examined through the use of Walden plots. To describe intermolecular interactions of the N-butylammonium carboxylate ILs, the optimized structures and energetics of ILs are calculated by DFT calculations. The calculated energies showed that the increase in the interaction energies between the ion clusters is the same as the trend of experimental viscosities.
Density, viscosity, and refractive index properties for the binary mixtures of n -butylammonium acetate ionic liquid + alkanols at sveral temperatures
Xu, Yingjie,Yao, Jia,Wang, Congmin,Li, Haoran
, p. 298 - 308 (2012)
Densities and viscosities were determined for the binary mixtures of n-butylammonium acetate ionic liquid (N4AC) with methanol, ethanol, n-propanol, and n-butanol at temperatures of (293.15, 298.15, 303.15, 308.15, and 313.15) K under atmospheric pressure. The refractive indices of the above-mentioned binary mixtures were measured at 298.15 K. Excess molar volumes VE, viscosity deviations Δη, and refractive index deviations Δn D were obtained from the experimental data and fitted with the Redlich-Kister equation. The correlation results were in good agreement with the experimental data, and optimal fitting parameters were presented. The results were interpreted in terms of interactions and structural factors of N4AC + alkanols mixtures.
Synthesis and characterization of new low-cost ILs based on butylammonium cation and application to lignocellulose hydrolysis
De Andrade Neto, José Carlos,De Souza Cabral, Allex,De Oliveira, Lucas Rissato Dognani,Torres, Ricardo Belchior,Morandim-Giannetti, Andreia De Araújo
, p. 279 - 287 (2016/03/01)
Fourteen ionic liquids (ILs) were obtained and characterized by nuclear magnetic resonance and infra-red spectroscopy. One of these liquids, n-butylammonium acetate, was used in the treatment of coir fiber prior to acid hydrolysis. For this purpose, the fiber was pulped with 8% (w/w) sodium hydroxide for 6 h under 2.5 atm pressure at 137 °C and then treated with IL for 2 h at 90 °C. The samples were hydrolyzed in acetic acid at different concentrations and temperatures. The reducing sugar concentrations were determined in all samples, and the optimal hydrolysis conditions were established (32.2% acetic acid at 122.4 °C). The reaction time was also studied, and the conversion was maximized at 3 h. Under the best hydrolysis conditions, crude fiber, pulping fiber, and IL-treated fiber were hydrolyzed to yield 8.53%, 47.58%, and 89.75% of reducing sugars, respectively.
