16507-88-3

Basic information

• Product Name: <α-Hydroxy-α-methyl-benzyl>-methyl-<1>naphthyl-phenyl-silan
• CAS NO: 16507-88-3
• Molecular Weight: 368.55
• Mol File: 16507-88-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: <α-Hydroxy-α-methyl-benzyl>-methyl-<1>naphthyl-phenyl-silan(CAS DataBase Reference)
• NIST Chemistry Reference: <α-Hydroxy-α-methyl-benzyl>-methyl-<1>naphthyl-phenyl-silan(16507-88-3)
• EPA Substance Registry System: <α-Hydroxy-α-methyl-benzyl>-methyl-<1>naphthyl-phenyl-silan(16507-88-3)

Safety Data

• Hazardous Substances Data: 16507-88-3(Hazardous Substances Data)

Upstream product

• 149-74-6 dichloromethylphenylsilane 
• 14474-59-0 naphthalen-1-yl-lithium 
• 15719-27-4 Methyl-(2-methyl-[1,3]dithian-2-yl)-naphthalen-1-yl-phenyl-silane 
• 138380-27-5 (1-ethoxyethenyl)methyl(naphth-1-yl)phenylsilane 
• 960-82-7 rac-methyl(1-naphthyl)phenylchlorosilane 
• 138457-71-3 methyl ketone 
• 591-51-5 phenyllithium 

Relevant articles and documents

Chiral Acylsilanes in Organic Synthesis. Diastereoselective 1,2 Additions to Racemic Alkoxymethyl-Substituted Acylsilanes

The synthesis of the three alkoxymethyl-sustituted acylsilanes 1-3 is described (Schemes 1 and 2).Their reactions with NaBH4 as well as PhLi gave the corresponding alcohols with moderate to good diastereoisomeric induction (up to 78percent de; see Table), depending upon the solvent used (Scheme 3).The results indicate that in Et2O, the reactions with PhLi proceed via 6-membered chelates (see C in Scheme 4) leading to the products with high de's (74 - 78percent).In THF, these chelates are not formed, and as a consequence, the additions take place with reversed and lower stereoselectivities (34 - 50percent de).