16535-88-9Relevant articles and documents
Copper-Catalyzed Formation of α-Alkoxycycloalkenones from N-Tosylhydrazones
Su, Naijing,Theorell, Juliana A.,Wink, Donald J.,Driver, Tom G.
supporting information, p. 12942 - 12946 (2015/11/02)
The combination of 20 mol % of copper iodide and lithium tert-butoxide triggers the formation of a broad range of substituted, functionalized α-alkoxy 2H-naphthalenones from readily available N-tosylhydrazones. The data suggests that this transformation occurs through cycloaddition of a copper carbenoid with an ester, followed by a Lewis acid-catalyzed [1,2] alkyl shift of the in situ generated alkoxyepoxide intermediate. The combination of 20 mol % of copper iodide and lithium tert-butoxide triggers the formation of a broad range of substituted, functionalized α-alkoxy 2H-naphthalenones from readily available N-tosylhydrazones. The reaction proceeds by the cycloaddition of a copper carbenoid with an ester, and a subsequent Lewis acid-catalyzed [1,2] alkyl shift of the in situ generated alkoxyepoxide intermediate.
The direct acyl-alkylation of arynes. Preparation of methyl 2-(2-Acetylphenyl)acetate
Ebner, David C.,Tambar, Uttam K.,Stoltz, Brian M.,Storgaard, Morten,Ide, Nathan D.,Ragan, John A.,Ellman, Jonathan A.
experimental part, p. 161 - 171 (2011/03/21)
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The direct acyl-alkylation of arynes
Tambar, Uttam K.,Stoltz, Brian M.
, p. 5340 - 5341 (2007/10/03)
An efficient and mild acyl-alkylation of arynes is described. The method is used to synthesize medium-sized carbocycles by the ring-expansion of cyclic β-ketoesters. Copyright