165387-78-0Relevant articles and documents
Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres
Cohen, Frederick,Koehler, Michael F.T.,Bergeron, Philippe,Elliott, Linda O.,Flygare, John A.,Franklin, Matthew C.,Gazzard, Lewis,Keteltas, Stephen F.,Lau, Kevin,Ly, Cuong Q.,Tsui, Vickie,Fairbrother, Wayne J.
scheme or table, p. 2229 - 2233 (2010/06/15)
A series of IAP antagonists based on thiazole or benzothiazole amide isosteres was designed and synthesized. These compounds were tested for binding to the XIAP-BIR3 and ML-IAP BIR using a fluorescence polarization assay. The most potent of these compound
INHIBITORS OF IAP
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, (2008/06/13)
The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula (I): wherein Q, X1, X2, Y, Z1, Z2, Z3, Z4, R1, R2, R3, R3', R4, R4', R5, R6, R6' and n are as described herein.
Method for preparing 3-amino-2-chloro-4-alkylpyridine or-4-arylpyridine
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, (2008/06/13)
The present invention relates to a new process for preparing 3-amino-2-chloro-4-alkyl- or -4-aryl-pyridines on an industrial scale.