1667-12-5

Basic information

• Product Name: 4,4'-Bis(hydroxymethyl)biphenyl
• Synonyms: DIPHENYL-4,4'-DIMETHANOL;(4'-HYDROXYMETHYL-BIPHENYL-4-YL)-METHANOL;4,4'-BIPHENYLDIMETHANOL;4,4'-BIS(HYDROXYMETHYL)BIPHENYL;4,4'-BISBENZYL ALCOHOL;[1,1ˊ-biphenyl] 4,4ˊ-dimethanol;4,4''-BIS(HYDROXYMETHYL)BIPHENYL 96%(HPLC);4,4'-Biphenyldimethanol
• CAS NO: 1667-12-5
• Molecular Formula: C₁₄H₁₄O₂
• Molecular Weight: 214.26
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;pharmacetical;Biphenyls (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research
• Mol File: 1667-12-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 191-192°C
• Boiling Point: 416.341 °C at 760 mmHg
• Flash Point: 204.517 °C
• Appearance: /
• Density: 1.175 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: almost transparency in hot EtOH
• PKA: 14.01±0.10(Predicted)
• CAS DataBase Reference: 4,4'-Bis(hydroxymethyl)biphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-Bis(hydroxymethyl)biphenyl(1667-12-5)
• EPA Substance Registry System: 4,4'-Bis(hydroxymethyl)biphenyl(1667-12-5)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 1667-12-5(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Upstream product

• 3883-85-0 4,4'-bis(acetoxymethyl)biphenyl 
• 787-70-2 4,4'-diphenic acid 
• 92-52-4 biphenyl 
• 792-74-5 4,4'-biphenyldicarboxylic acid dimethyl ester 
• 7732-18-5 water 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 195062-62-5 ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 586-76-5 4-Bromobenzoic acid 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 47230-38-6 diethyl biphenyl-4,4'-dicarboxylate 
• 2351-37-3 4,4'-biphenyldicarboxylic acid dichloride 
• 20248-86-6 4-4'-bis(bromomethyl)biphenyl 
• 1667-10-3 4,4'-bis(chloromethyl)biphenyl 
• 88234-22-4 N,N'-dimethyl-N,N'-diphenyl-biphenyl-4,4'-dicarboxamide 

Downstream Products

• 1667-10-3 4,4'-bis(chloromethyl)biphenyl 
• 20248-86-6 4-4'-bis(bromomethyl)biphenyl 
• 1266348-24-6 C₃₀H₂₂O₄ 
• 1266348-25-7 (2E,2′E)-3,3′-([1,1′-biphenyl]-4,4′-diyl)bis(1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one) 
• 1266348-23-5 C₃₀H₂₂O₂ 
• 106835-92-1 4,4'-Bis<(triphenylphosphonio)methyl>biphenyl-dibromid 
• 17919-34-5 4,4'-bis(diethoxyphosphinylmethyl)biphenyl 
• 79567-15-0 4,4'-di((E)-styryl)-1,1'-biphenyl 
• 613-33-2 (4,4'-dimethyl-1,1'-biphenyl) 

Relevant articles and documents

Synthesis of a [3.3]biphenylophane, and its photophysical and photochemical properties studied by emission and transient absorption measurements

[3.3](4,4′)Biphenylophane (BPP) is synthesized, and the photophysical and photochemical properties are studied by means of emission and transient absorption measurements. BPP emits excimer fluorescence at 295 and 77 K, and phosphorescence from the locally-excited (LE) triplet state at 77 K. Based on the transient absorption spectra of BPP, it is found that the excimeric triplet state of BPP is produced along with the LE triplet at 295 and 77 K. The triplet excimer of BPP is shown to be formed via intersystem crossing from the singlet excimer state, and concluded to be non-phosphorescent.

Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: A systematic investigation of the influence of linker and cationic heads over affinity and selectivity

A molecular library of quaternary ammonium salts (QASs), mainly composed of symmetrical bis-quaternary heterocyclic bromides exhibiting choline kinase (ChoK) inhibitory activity, were evaluated for their ability to inhibit acetyl- and butyrylcholinesterase (AChE and BChE, respectively). The molecular framework of QASs consisted of two positively charged heteroaromatic (pyridinium or quinolinium) or sterically hindered aliphatic (quinuclidinium) nitrogen rings kept at an appropriate distance by lipophilic rigid or semirigid linkers. Many homodimeric QASs showed AChE and BChE inhibitory potency in the nanomolar range along with a low enzymatic selectivity. Computational studies on AChE, BChE, and ChoK allowed identification of the key molecular determinants for high affinity and selectivity over either one of the three enzymes and guided the design of a hybrid bis-QAS (56) exhibiting the highest AChE affinity (IC50 = 15 nM) and selectivity over BChE and ChoK (SI = 50 and 562, respectively) and a promising pharmacological potential in myasthenia gravis and neuromuscular blockade.

Synthesis and properties of luminophores derived from fluorinated biphenyls

A procedure was developed for the synthesis of dimethyl 2-fluoro-and 2,2′-difluorobiphenyl-4,4′-dicarboxylates. The latter were converted into fluorinated 4,4′-bis[(E)-2-(1,3-benzoxazol-2-yl)ethenyl]-and 4,4′-bis[5-(4-octyloxyphenyl)-1,3,4-oxadiazol-2-yl]biphenyls which showed strong luminescence in the crystalline state and in solution; their spectral properties were examined.