16736-88-2

Basic information

• Product Name: 1-(naphthalen-2-yl)-3-phenylprop-2-yn-1-one
• Synonyms: 1-(naphthalen-2-yl)-3-phenylprop-2-yn-1-one
• CAS NO: 16736-88-2
• Molecular Weight: 256.304
• Mol File: 16736-88-2.mol
• Article Data: 33

Chemical Properties

• CAS DataBase Reference: 1-(naphthalen-2-yl)-3-phenylprop-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(naphthalen-2-yl)-3-phenylprop-2-yn-1-one(16736-88-2)
• EPA Substance Registry System: 1-(naphthalen-2-yl)-3-phenylprop-2-yn-1-one(16736-88-2)

Safety Data

• Hazardous Substances Data: 16736-88-2(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 3857-83-8 2-naphthyl triflate 
• 536-74-3 phenylacetylene 
• 478282-11-0 1-(2-naphthyl)-3-phenyl-prop-2-yn-1-ol 
• 580-13-2 2-bromonaphthalene 
• 2243-58-5 2-naphthylhydrazine hydrochloride 
• 612-55-5 2-iodonaphthalene 
• 2243-83-6 2-naphthaloyl chloride 
• 130576-52-2 N-(2-naphthoyl) saccharin 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 4440-01-1 lithium phenylacetylide 
• 66-99-9 β-naphthaldehyde 
• 25308-57-0 isopropyl 2-naphtalenecarboxylate 

Downstream Products

• 934817-32-0 2-(naphthalen-2-yl)-2-(2-phenylethynyl)-1,3-dithiolane 
• 1422018-23-2 (Z)-1-(naphthalen-2-yl)-3-phenylprop-2-yn-1-one O-methyl oxime 
• 1422018-10-7 3-(naphthalen-2-yl)-5-phenyl-4-(phenylselenyl)isoxazole 

Relevant articles and documents

Electrochemical Palladium-Catalyzed Oxidative Sonogashira Carbonylation of Arylhydrazines and Alkynes to Ynones

Oxidative carbonylation using carbon monoxide has evolved as an attractive tool to valuable carbonyl-containing compounds, while mixing CO with a stoichiometric amount of a chemical oxidant especially oxygen is hazardous and limits its application in scale-up synthesis. By employing anodic oxidation, we developed an electrochemical palladium-catalyzed oxidative carbonylation of arylhydrazines with alkynes, which is regarded as an alternative supplement of the carbonylative Sonogashira reaction. Combining an undivided cell with constant current mode, oxygen-free conditions avoids the explosion hazard of CO. A diversity of ynones are efficiently obtained using accessible arylhydrazines and alkynes under copper-free conditions. A possible mechanism of the electrochemical Pd(0)/Pd(II) cycle is rationalized based upon cyclic voltammetry, kinetic studies, and intermediates experiments.

Sc(OTf)3-catalyzed [3 + 2]-cycloaddition of nitrones with ynones

An efficient approach to access functionalized (2,3-dihydroisoxazol-4-yl) ketones has been developed by reacting nitrones 4 with ynones 7 or terminal ynones 10 in a one-pot fashion. The reaction went through a formal Sc(OTf)3-catalyzed [3 + 2]-cycloaddition process to generate a number of functionalized (2,3-dihydroisoxazol-4-yl) ketones 11aa-11aw, 11ba-11la and 12aa-12ae in moderate to good yields. This journal is

Synthesis of 2-isoxazolyl-2,3-dihydrobenzofuransviapalladium-catalyzed cascade cyclization of alkenyl ethers

A novel palladium-catalyzed cascade cyclization reaction of alkenyl ethers with alkynyl oxime ethers for the construction of poly-heterocyclic scaffolds has been developed, in which the electron-rich alkene moiety functions as a three-atom unit, simultaneously dealing well with the coordination and regioselectivity of electron-rich olefins under metal catalysis. The strategy features excellent regio- and chemoselectivities as well as good functional group tolerance. Moreover, the newly formed 2-isoxazolyl-2,3-dihydrobenzofuran products can be further transformed to diverse complex heterocycles, demonstrating their potential applications in organic synthesis and medicinal chemistry.