167637-41-4

Basic information

• Product Name: Ethyl-5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienoate
• Synonyms: 5-(4-Methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienoic Acid Ethyl Ester;Ethyl-5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienoate
• CAS NO: 167637-41-4
• Molecular Formula: C₁₈H₂₄O₃
• Molecular Weight: 288.38
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 167637-41-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Refractive Index: 1.535
• Solubility: Orange Yellow Oily Residue
• CAS DataBase Reference: Ethyl-5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl-5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienoate(167637-41-4)
• EPA Substance Registry System: Ethyl-5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienoate(167637-41-4)

Safety Data

• Hazardous Substances Data: 167637-41-4(Hazardous Substances Data)

Usage

Chemical Properties

Orange Yellow Oily Residue

Uses

Different sources of media describe the Uses of 167637-41-4 differently. You can refer to the following data:
1. An intermediate for the synthesis of analogs of retinoid lactone
2. An intermediate for the synthesis of analogs of retinoid lactone.

InChI:InChI=1/C18H24O3/c1-7-21-18(19)10-12(2)8-9-16-13(3)11-17(20-6)15(5)14(16)4/h8-11H,7H2,1-6H3/b9-8+,12-10+

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 54757-47-0 4-(4'-methoxy-2',3',6'-trimethylphenyl)-but-3-ene-2-one 
• 54344-92-2 2,3,6-trimethyl-4-methoxy-benzaldehyde 
• 697-82-5 2,3,5-trimethylphenol 
• 20469-61-8 2,3,5-trimethylanisole 

Downstream Products

• 419534-29-5 cis,cis-5-(4'-methoxy-2',3',6'-trimethylphenyl)-3-methylpenta-2,4-dienal 
• 69877-38-9 5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-2(E),4(E)-pentadien-1-al 
• 167637-42-5 5-(4'-methoxy-2',3',6'-trimethylphenyl)-3-methylpenta-2,4-dienol 

Relevant articles and documents

Evaluation of retinoid lactones as topical therapeutic agents in dermatology

Purpose. Optimization of the therapeutic ratio of analogs of the topically active 11-cis,13-cis-12-hydroxymethylretinoic acid, δ-lactone (I) relative to antihyperproliferation and antihyperkeratinization vs. toxicity. Methods. Nine analogs of 1, in which variations were made in the lipophilic cyclohexenyl moiety or in the lactone ring, were evaluated for topical activity against hyperkeratinization, inhibition of TPA-induced DNA synthesis and for skin irritation. Results. Although more potent lactones than the parent lactone 1 were identified, none possessed the favorable therapeutic ratio associated with 1. Conclusions. The δ-lactone 1 possesses unique molecular features responsible for its desirable therapeutic ratio as an anti-hyperproliferative and antihyperkeratotic agent. In view of its very low systemic retinoid toxicity and the absence of any systemic toxicity, this lactone may be a good candidate for use in the topical treatment of acne.