167843-57-4Relevant articles and documents
Conversion of the LXR-agonist TO-901317-From inverse to normal modulation of γ-secretase by addition of a carboxylic acid and a lipophilic anchor
Narlawar, Rajeshwar,Baumann, Karlheinz,Czech, Christian,Schmidt, Boris
, p. 5428 - 5431 (2007)
TO-901317, a LXR agonist, is an inverse modulator of Alzheimer's disease associated γ-secretase. We synthesized TO-901317 analogous compound but replaced the hexafluorocarbinol moiety by an oxyacetic acid functionality and hypothesized that the replacemen
QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS
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, (2015/09/23)
The present invention is directed to quinoline derivatives, pharmaceutical compositions containing said derivatives and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, in the treatment of disorders
PPAR AGONIST COMPOUNDS, PREPARATION AND USES
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Page/Page column 20, (2011/08/22)
The present invention relates to novel PPAR agonist compounds as well as pharmaceutical compositions containing them. The compounds according to the invention are of quite particular therapeutic interest, notably for treating diabetes and/or dyslipidemias, as well as for preventing cardiovascular pathologies.