169280-26-6

Basic information

• Product Name: 2-(4-(1-Oxo-1-cyclopropanyl)-phenyl)-2-methylpropanol
• Synonyms: 2-(4-(1-Oxo-1-cyclopropanyl)-phenyl)-2-methylpropanol
• CAS NO: 169280-26-6
• Molecular Weight: 218.296
• Mol File: 169280-26-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-(1-Oxo-1-cyclopropanyl)-phenyl)-2-methylpropanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(1-Oxo-1-cyclopropanyl)-phenyl)-2-methylpropanol(169280-26-6)
• EPA Substance Registry System: 2-(4-(1-Oxo-1-cyclopropanyl)-phenyl)-2-methylpropanol(169280-26-6)

Safety Data

• Hazardous Substances Data: 169280-26-6(Hazardous Substances Data)

Usage

Compound classification

Cycloalkanol It is a type of alcohol that contains a cycloalkane group, which is a saturated hydrocarbon ring.

Derivative

Phenylcyclohexanol derivative This compound is derived from phenylcyclohexanol, which is a type of cycloalkanol.

Physical state

Colorless liquid It is a liquid without any color, which is a common state for many organic compounds.

Applications

Pharmaceutical and organic compound production 2-(4-(1-Oxo-1-cyclopropanyl)-phenyl)-2-methylpropanol is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds.

Potential applications

Medical and industrial chemistry It has potential uses in both the medical and industrial fields, but further research is needed to fully understand its properties and applications.

Research status

Additional research needed More studies are required to explore the properties and potential uses of 2-(4-(1-Oxo-1-cyclopropanyl)-phenyl)-2-methylpropanol in various fields.

Upstream product

• 71-43-2 benzene 
• 18755-52-7 (2-acetoxy-1,1-dimethylethyl)benzene 
• 169032-11-5 2-(4-(4-Chloro-1-oxo-butyl))-phenyl-2-methyl propanyl acetate 
• 515-40-2 neophyl chloride 
• 480466-35-1 1-acetoxy-2-methyl-2-[3-(4-chlorobutyryl)phenyl]propane 
• 169280-25-5 2-(4-(4-Chloro-1-oxo-butyl))-phenyl-2-methylpropanol 
• 169280-24-4 2-(4-(1-Oxo-1-cyclopropanyl)-phenyl)-2-methyl propanyl acetate 

Downstream Products

• 162096-54-0 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionic acid 
• 713528-02-0 cyclopropyl keto α,α-dimethylphenyl acetic acid 
• 154477-54-0 2-[4-(4-Chloro-butyryl)-phenyl]-2-methyl-propionic acid, methyl ester 
• 76811-97-7 4-(4-chloro-1-oxobutyl)-α,α-dimethylbenzeneacetic acid ethyl ester 
• 1448311-89-4 4-(4-chloro-1-hydroxyl-butyl)-α,α-dimethyl phenyl acetic acid ethyl ester 
• 174483-06-8 ethyl 4-[4[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetate 
• 83799-24-0 fexofenadine 

Relevant articles and documents

The synthesis of fexofenadine

This work proposes a new simple route for fexofenadine synthesis with low cost and easily obtainable raw materials. We use benzene and methallyl as starting reactants, applying steps of Friedel-Crafts alkylation reaction, hydrolysis, oxidation, esterification reaction, and reduction reaction to obtain the intermediate product, followed by N-alkylation reaction to obtain 4-{1-hydroxy-4-[4-(hydroxydiphenyl)-piperidine]butyl}-α, α-dimethylbenzene acetate. Then, the final product fexofenadine is obtained upon hydrolysis. In the synthesis process, we constantly optimize the reaction conditions such as reaction time, reaction temperature, solvent selection, and other factors, thus improving the final yield of the target product fexofenadine to 33.51 %.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula whereinW represents —C(=O)— or —CH(OH)—;R1 represents hydrogen or hydroxy;R2 represents hydrogen;R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2;n is an integer of from 1 to 5;m is an integer 0 or 1;R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; andpharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1represents hydrogen or hydroxy; R2represents hydrogen; R1and R2taken together form a second bond between the carbon atoms bearing R1and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1and R2are taken together to form a second bond between the carbon atoms bearing R1and R2or where R1represented hydroxy, m is an integer 0.