170961-15-6

Basic information

• Product Name: Carbamic acid, 2-thiazolyl-, 1,1-dimethylethyl ester (9CI)
• Synonyms: 2-t-butoxycarbonylamino-1,3-thiazole;Carbamic acid, 2-thiazolyl-, 1,1-dimethylethyl ester (9CI);N-Boc-2-AMinothiazole;2-(tert-ButoxycarbonylaMino)thiazole;1-(Boc-aMino)thiazole, 97%;Thiazol-2-yl-carbaMic acid tert-butyl ester;2-(Boc-aMino)thiazole, 97%;CarbaMic acid, 2-thiazolyl-
• CAS NO: 170961-15-6
• Molecular Formula: C₈H₁₂N₂O₂S
• Molecular Weight: 200.25808
• Product Categories: N-BOC
• Mol File: 170961-15-6.mol
• Article Data: 31

Chemical Properties

• Melting Point: 180-185℃
• Appearance: /
• Density: 1.242±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 5.25±0.70(Predicted)
• CAS DataBase Reference: Carbamic acid, 2-thiazolyl-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, 2-thiazolyl-, 1,1-dimethylethyl ester (9CI)(170961-15-6)
• EPA Substance Registry System: Carbamic acid, 2-thiazolyl-, 1,1-dimethylethyl ester (9CI)(170961-15-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 170961-15-6(Hazardous Substances Data)

Usage

General Description

Carbamic acid, 2-thiazolyl-, 1,1-dimethylethyl ester (9CI) is a chemical compound belonging to the family of thiazoles, which are aromatic heterocyclic compounds characterized by a five-membered aromatic ring containing one nitrogen atom and one sulfur atom. As an ester, it is the product of a reaction between an alcohol and an acid. This chemical's specific configuration suggests that it has potential applications in the field of organic synthesis, where it can be used in the formulation of more complex chemical structures. The precise properties and safety concerns of this compound, including its reactivity, stability, and toxicity, would need to be evaluated for specific utilizations.

Upstream product

• 96-50-4 2-thiazolylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 769069-45-6 tert-butyl N-chlorocarbamate 
• 4248-19-5 tert-butyl carbazate 
• 288-47-1 1,3-thiazole 
• 73210-14-7 N-chloro-N-sodio-tert-butylcarbamate 
• 1538-75-6 2,2-dimethylpropanoic anhydride 

Downstream Products

• 1081314-08-0 tert-butyl-{5-[hydroxy(3-trifluoromethylphenyl)methyl]thiazol-2-yl}carbamate 
• 479198-74-8 2-(N-tert-butoxycarbonyl-N-methyl-amino)-thiazole 
• 405939-39-1 tert-butyl 5-bromothiazol-2-ylcarbamate 
• 1202278-30-5 tert-butyl isopropyl(5-(8-phenylimidazo[1,2-a]pyrazin-6-yl)thiazol-5-yl)carbamate 
• 1202278-29-2 tert-butyl 5-(5-amino-6-phenylpyrazin-2-yl)thiazol-2-yl(isopropyl)carbamate 
• 1093192-90-5 methyl 4-((2-(tert-butoxycarbonylamino)thiazol-5-yl)buta-1,3-diynyl)benzoate 
• 1093192-91-6 4-((2-(tert-butoxycarbonylamino)thiazol-5-yl)buta-1,3-diynyl)benzoic acid 
• 1314095-64-1 tert-butyl 5-bromothiazol-2-yl(methyl)carbamate 
• 957147-21-6 (5-trimethylsilanylethynyl-thiazol-2-yl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Nanoceria as an efficient and green catalyst for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions

Nanocerium oxide mediated an efficient and green protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at ambient temperature. Various aliphatic, aromatic and heteroaromatic amines were protected using developed protocol and several functional groups such as alcohol, phenol and ester were well tolerated under these conditions. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

Design and synthesis of aminothiazole based Hepatitis B Virus (HBV) capsid inhibitors

The capsid assembly is an essential step for Hepatitis B Virus (HBV) life cycle and is an important target for anti-HBV drug development. In this report, we identified a hit compound with aminothiazole structure by the high throughput screening (HTS) which inhibited the interaction of HBV capsid protein within the cells. The structure hopping and SAR studies of the hit compound afforded compound 79 with potent anti-HBV replication activity and good basic drug-like properties. The working mechanism studies showed that compound 79 could bind to the similar binding site of known HBV capsid inhibitor with heteroaryldihydropyrimidine (HAP) scaffold, through similar hydrophobic interactions but with a different hydrogen bond. This compound exerted potent inhibitory effect upon HBV production, either in cell culture or in mice with no obvious acute toxicity. We propose that further development of this compound could lead to novel potent anti-HBV inhibitors that target HBV capsid assembly.