405939-39-1

Basic information

• Product Name: N-BOC-2-AMINO-5-BROMOTHIAZOLE
• Synonyms: tert-butyl N-(5-broMo-1,3-thiazol-2-yl)carbaMate;TERT-BUTYL (5-BROMO-1,3-THIAZOL-2-YL)CARBAMATE;TERT-BUTYL 5-BROMOTHIAZOL-2-YLCARBAMATE;N-BOC-2-AMINO-5-BROMOTHIAZOLE;N-Boc-2-Amino-5-bromothiazole95%;(5-BroMo-thiazol-2-yl)-carbaMic acid tert-butyl ester;2-(Boc-aMino)-5-broMothiazole
• CAS NO: 405939-39-1
• Molecular Formula: C₈H₁₁BrN₂O₂S
• Molecular Weight: 279.15414
• Product Categories: Thiazole;API intermediates
• Mol File: 405939-39-1.mol
• Article Data: 30

Chemical Properties

• Appearance: /Solid
• Density: 1.574 g/cm³
• Refractive Index: 1.596
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.58±0.70(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: N-BOC-2-AMINO-5-BROMOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-2-AMINO-5-BROMOTHIAZOLE(405939-39-1)
• EPA Substance Registry System: N-BOC-2-AMINO-5-BROMOTHIAZOLE(405939-39-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 405939-39-1(Hazardous Substances Data)

Usage

General Description

N-BOC-2-amino-5-bromothiazole is a chemical compound with the molecular formula C10H12BrN3OS. It is a derivative of 2-amino-5-bromothiazole and contains a BOC (tert-butyloxycarbonyl) protecting group on the amino group. N-BOC-2-AMINO-5-BROMOTHIAZOLE has potential use in the synthesis of pharmaceuticals and agrochemicals due to its unique structure and reactivity. It is also used as a building block in organic synthesis and medicinal chemistry research. N-BOC-2-amino-5-bromothiazole is a valuable chemical that has many applications in the field of chemistry and biochemistry.

InChI:InChI=1/C8H11BrN2O2S/c1-8(2,3)13-7(12)11-6-10-4-5(9)14-6/h4H,1-3H3,(H,10,11,12)

Upstream product

• 3034-22-8 5-bromo-2-aminothiazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 170961-15-6 tert-butyl 1,3-thiazole-2-yl-carbamate 
• 61296-22-8 5-bromothiazol-2-amine hydrobromide 
• 4248-19-5 tert-butyl carbazate 
• 957346-62-2 5-bromo-1,3-thiazole-2-carboxylic acid 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 881402-27-3 tert-butyl (5-bromothiazol-2-yl)(4-methoxybenzyl)carbamate 
• 731018-54-5 2-(tert-butoxycarbonyl)amino-5-fluorothiazole 
• 1081314-08-0 tert-butyl-{5-[hydroxy(3-trifluoromethylphenyl)methyl]thiazol-2-yl}carbamate 
• 944804-72-2 (S)-tert-butyl 1-(N-(5-bromothiazol-2-yl)-tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)propan-2-ylcarbamate 
• 1245647-27-1 (5-Vinyl-thiazol-2-yl)-carbamic acid tert-butyl ester 
• 944805-17-8 tert-butyl (4-bromo-5-formylthiazol-2-yl)carbamate 
• 1355249-32-9 C₂₅H₃₀N₄O₇S 
• 1355249-33-0 C₂₁H₂₆N₄O₅S 
• 1312572-74-9 tert-butyl [5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbamate 

Relevant articles and documents

Halogen-Dance-Based Synthesis of Phosphonomethoxyethyl (PME) Substituted 2-Aminothiazoles as Potent Inhibitors of Bacterial Adenylate Cyclases

A series of acyclic nucleoside phosphonates (ANPs) was designed as inhibitors of bacterial adenylate cyclases (ACs), where adenine was replaced with 2-amino-4-arylthiazoles. The target compounds were prepared using the halogen dance reaction. Final AC inh

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.