171046-58-5Relevant articles and documents
Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: Orally active prostacyclin mimetics. Part 6
Tanaka, Akira,Hattori, Kouji,Taniguchi, Kiyoshi,Okitsu, Osamu,Tabuchi, Seiichiro,Nishio, Mie,Nagakura, Yasunori,Maeda, Noriaki,Murai, Hidetsugu,Seki, Jiro
, p. 4861 - 4864 (2007/10/03)
The synthesis and biological activity of novel derivatives of our previously reported IP receptor agonist FR181157 is described. SAR studies to replace the cyclohexene-linker of FR181157 led to the discovery of compound 1i (FR207845) as a potent non-prost