1721-13-7

Basic information

• Product Name: 2,6-DIMETHYL-NICOTINIC ACID ETHYL ESTER
• Synonyms: 2,6-DIMETHYL-NICOTINIC ACID ETHYL ESTER;AURORA KA-3069;2,6-Dimethyl nicotine acid ethyl ester;2,6-dimethylnicotin ethyl ester;ethyl 2,6-dimethylpyridine-3-carboxylate;2, 6-dimethyl-3-pyridinecarboxylic acid ethyl ester;Ethyl 2,6-dimethyl nicotinate
• CAS NO: 1721-13-7
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 1721-13-7.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 232.8 °C at 760 mmHg
• Flash Point: 94.6 °C
• Appearance: /
• Density: 1.056 g/cm³
• Vapor Pressure: 0.0578mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.74±0.10(Predicted)
• CAS DataBase Reference: 2,6-DIMETHYL-NICOTINIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIMETHYL-NICOTINIC ACID ETHYL ESTER(1721-13-7)
• EPA Substance Registry System: 2,6-DIMETHYL-NICOTINIC ACID ETHYL ESTER(1721-13-7)

Safety Data

• Hazardous Substances Data: 1721-13-7(Hazardous Substances Data)

Usage

General Description

2,6-DIMETHYL-NICOTINIC ACID ETHYL ESTER is a chemical compound with the molecular formula C12H17NO2. It is an ester derivative of 2,6-dimethyl-nicotinic acid, which is a derivative of niacin (vitamin B3). 2,6-DIMETHYL-NICOTINIC ACID ETHYL ESTER is commonly used in the pharmaceutical industry as a building block for the synthesis of various drug molecules such as antifungal agents and antihypertensive drugs. It has also been studied for its potential use in the treatment of neurodegenerative diseases and inflammatory conditions. The chemical structure of 2,6-DIMETHYL-NICOTINIC ACID ETHYL ESTER includes a nicotinic acid moiety, which is known for its biological activity and potential therapeutic applications.

InChI:InChI=1/C10H13NO2/c1-4-13-10(12)9-6-5-7(2)11-8(9)3/h5-6H,4H2,1-3H3

Upstream product

• 141-97-9 ethyl acetoacetate 
• 77287-34-4 formamide 
• 593-67-9 vinylamine 
• 75-07-0 acetaldehyde 
• 35490-05-2 2-acetyl-5-oxohexanoic acid ethyl ester 
• 626-34-6 ethyl aminocrotonate 
• 78-94-4 methyl vinyl ketone 
• 626-34-6 ethyl 3-aminobut-2-enoate 
• 2028-63-9 but-3-yn-2-ol 
• 5930-98-3 4-trimethylsilyl-3-butyn-2-one 
• 1423-60-5 methyl ethynyl ketone 
• 480453-20-1 (4E)-2-amino-3-ethoxycarbonylhepta-2,4-dien-6-one 
• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 
• 70271-80-6 ethyl 4-chloro-2,6-dimethylnicotinate 

Downstream Products

• 672325-49-4 (2,6-dimethylpyridin-3-yl)methanamine 
• 113056-89-6 2,6-bis-(3-nitro-trans-styryl)-nicotinic acid 
• 108619-14-3 2-methyl-6-(3-nitro-trans-styryl)-nicotinic acid 
• 101876-19-1 6-((αRS,βSR)-α,β-dibromo-phenethyl)-2-methyl-nicotinic acid ethyl ester 
• 136819-91-5 2-Methyl-6-styryl-3-nicotinic acid 
• 1462-84-6 2,3,6-trimethylpyridine 
• 108-48-5 2,6-dimethylpyridine 
• 118420-52-3 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(2,6-dimethyl-pyridin-3-yl)-acrylamide 
• 650141-20-1 2,6-dimethylpyridine-3-carboxaldehyde 
• 5860-71-9 2,6-dimethylpyridine-3-carboxylic acid 
• 582303-10-4 (2,6-dimethylpyridin-3-yl)methanol 
• 1721-25-1 1-(2,6-dimethylpyridin-3-yl)ethan-1-one 
• 102452-11-9 (+/-)-7-phenyl-2-trans-styryl-7,8-dihydro-pyrano[4,3-b]pyridin-5-one 
• 109471-60-5 2-methyl-6-trans-styryl-nicotinic acid ethyl ester 

Relevant articles and documents

A new one-pot three-component condensation reaction for the synthesis of 2,3,4,6-tetrasubstituted pyridines

The one-pot three-component condensation of a β-ketoester, ammonia and an alkynone in the presence of a Bronsted or Lewis acid or Amberlyst 15 ion exchange resin provided 2,3,6-trisubstituted or 2,3,4,6-tetrasubstituted pyridines directly in good yield and with total regiocontrol.

Synthesis of pyridines and pyrido[2,3-d]pyrimidines by the Lewis acid catalysed Bohlmann-Rahtz heteroannulation reaction

Lewis acids catalyse the Bohlmann-Rahtz heteroannulation reaction to generate highly functionalised pyridines from enamino esters and alkynones in a single synthetic step. Of the catalysts studied, ytterbium(III) trifluoromethanesulfonate and zinc(II) bromide are the two most efficient for the synthesis of pyridines and pyrido[2,3-d]pyrimidines, from ethyl β-aminocrotonate or 2,6-di-aminopyrimidin-4-one respectively, in up to 94% yield.

Bohlmann-Rahtz cyclodehydration of aminodienones to pyridines using N-iodosuccinimide

Cyclodehydration of Bohlmann-Rahtz aminodienone intermediates using N-iodosuccinimide as a Lewis acid proceeds at low temperature under very mild conditions to give the corresponding 2, 3,6-trisubstituted pyridines in high yield and with total regiocontrol.

Alpha-substituted arylalkyl phosphonate derivatives

The present invention relates to novel α-substituted arylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lo