2028-63-9

Basic information

• Product Name: 3-Butyn-2-ol
• Synonyms: 1-Ethynylethanol;1-Methyl-2-propynyl alcohol;1-Methylpropargyl alcohol;3-butyn-2-0l;3-butyn-2-olsolution;3-Hydroxy-1-butyne;alpha-Methylpropargyl alcohol;but-3-yn-2-ol
• CAS NO: 2028-63-9
• Molecular Formula: C₄H₆O
• Molecular Weight: 70.09
• EINECS: 217-978-1
• Product Categories: Aliphatics;Acetylenes;Acetylenic Alcohols & Their Derivatives;Alkynes;Organic Building Blocks;Terminal
• Mol File: 2028-63-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: -1.5°C
• Boiling Point: 66-67 °C150 mm Hg(lit.)
• Flash Point: 78 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 0.950 g/mL at 20 °C
• Vapor Pressure: 17.3mmHg at 25°C
• Refractive Index: n20/D 1.426(lit.)
• Storage Temp.: Flammables area
• PKA: 13.28±0.20(Predicted)
• Water Solubility: Completely miscible in water
• BRN: 635722
• CAS DataBase Reference: 3-Butyn-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butyn-2-ol(2028-63-9)
• EPA Substance Registry System: 3-Butyn-2-ol(2028-63-9)

Safety Data

• Hazard Codes: T,F
• Statements: 10-25-36/38-36/37/38-24/25
• Safety Statements: 26-45-36/37/39-16
• RIDADR: UN 2929 6.1/PG 2
• WGK Germany: 3
• RTECS: ES0709800
• F: 10
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 2028-63-9(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to light yellow liquid

Flammability and Explosibility

Flammable

InChI:InChI=1/C4H6O/c1-3-4(2)5/h1,4-5H,2H3/t4-/m1/s1

Synthetic route

trimethyl(4-{[(1-methylprop-2-yn-1-yl)oxy]methyl}benzyl)silane (846539-19-3) → p-<(trimethylsilyl)methyl>benzaldehyde (109088-53-1) + but-3-yn-2-ol (2028-63-9)

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 20℃;	A n/a B 74%

acetaldehyde (75-07-0) + acetylene (74-86-2) → but-3-yn-2-ol (2028-63-9)

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 15℃;	10%
With potassium hydroxide; Dimethoxymethane; sodium amide
With potassium hydroxide; 2-methoxy-ethanol; sodium amide

Propargylic aldehyde (624-67-9) + methylmagnesium bromide (75-16-1) → but-3-yn-2-ol (2028-63-9)

Conditions	Yield
With diethyl ether

2-bromo-1-buten-3-ol (198014-16-3) → but-3-yn-2-ol (2028-63-9)

Conditions	Yield
With potassium hydroxide

ethynyldimagnesium dibromide (4301-15-9) + acetaldehyde (75-07-0) → but-3-yn-2-ol (2028-63-9)

Conditions	Yield
With diethyl ether; ethanol

sodium acetylide (1066-26-8) + acetaldehyde (75-07-0) → but-3-yn-2-ol (2028-63-9)

Conditions	Yield
at -5℃;
at -5℃;
With ammonia

diethyl ether (60-29-7) + ethylmagnesium bromide (925-90-6) + acetaldehyde (75-07-0) + acetylene (74-86-2) → but-3-yn-2-ol (2028-63-9)

acetaldehyde (75-07-0) + acetylene (74-86-2) → 3-hexyn-2,5-diol (3031-66-1) + but-3-yn-2-ol (2028-63-9)

Conditions	Yield
With copper acetylenide upon Fuller's earth; water at 120 - 125℃; under 11400 Torr;
With Fuller's Earth; water; copper(I) monacetylide at 125℃; under 11032.6 Torr; Gemisch von zwei Formen;
With Fuller's Earth; water; copper(I) monacetylide at 125℃; under 11032.6 Torr; Gemisch von zwei Formen;
With copper acetylenide upon Fuller's earth; water at 120 - 125℃; under 11400 Torr;

diethyl ether (60-29-7) + ethylmagnesium bromide (925-90-6) + acetylene (74-86-2) → but-3-yn-2-ol (2028-63-9)

Conditions	Yield
anschl. mit Acetaldehyd;

ethylmagnesium bromide (925-90-6) + acetylene (74-86-2) → but-3-yn-2-ol (2028-63-9)

Conditions	Yield
With diethyl ether nachfolgende Einw. von Acetaldehyd;

2-bromo-1-buten-3-ol (198014-16-3) + aqueous KOH-solution → but-3-yn-2-ol (2028-63-9)

methyl ethynyl ketone (1423-60-5) → but-3-yn-2-ol (2028-63-9)

Conditions	Yield
With sodium tetrahydroborate In ethanol at 0℃; for 1h;

acetaldehyde (75-07-0) + lithium acetylide (70277-75-7) → but-3-yn-2-ol (2028-63-9)

acetaldehyde (75-07-0) + acetylenemagnesium bromide (4301-14-8) → but-3-yn-2-ol (2028-63-9)

Conditions	Yield
In tetrahydrofuran at 0 - 20℃;
Stage #1: acetaldehyde; acetylenemagnesium bromide In tetrahydrofuran at -20 - 20℃; Inert atmosphere; Stage #2: With ammonium chloride In tetrahydrofuran at 0℃; Inert atmosphere;
In tetrahydrofuran at 0℃; for 5h;
In tetrahydrofuran at -78 - 20℃; for 2.5h; Inert atmosphere;

4-trimethylsilyl-3-butyn-2-ol (103253-60-7, 121522-26-7, 121522-27-8, 6999-19-5) → but-3-yn-2-ol (2028-63-9)

Conditions	Yield
With potassium carbonate In methanol at 20℃; for 2h; Inert atmosphere;

2-hydroxypropanal (3913-65-3) + dimethyl 1-(1-diazo-2-oxopropyl)phosphonate (90965-06-3) → but-3-yn-2-ol (2028-63-9)

Conditions	Yield
With potassium carbonate In methanol at 20℃; for 5.5h; Seyferth-Gilbert Homologation;

but-3-yn-2-ol (2028-63-9) → methyl ethynyl ketone (1423-60-5)

Conditions	Yield
With dihydrogen peroxide In toluene at 70℃; for 8.5h; Reagent/catalyst;	100%
With titanium(IV) oxide; oxygen at 29.84℃; under 760.051 Torr; for 24h; Sealed tube; Irradiation;	77%
With chromium(VI) oxide; sulfuric acid at 2 - 10℃; under 30 Torr; for 3h;	38%

but-3-yn-2-ol (2028-63-9) → 1-iodo-buta-1,2-diene (2914-57-0)

Conditions	Yield
With 1-iodo-N,N,2-trimethylprop-1-en-1-amine In dichloromethane 1.) 0 deg C; 2.) rt., 4 days;	100%
With triphenyl phosphite methiodide In N,N-dimethyl-formamide
Stage #1: but-3-yn-2-ol With n-butyllithium In tetrahydrofuran at -78℃; for 0.0833333h; Inert atmosphere; Stage #2: With methanesulfonyl chloride In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #3: With copper(l) iodide; lithium iodide In tetrahydrofuran at -78 - 20℃; Inert atmosphere;

methanesulfonyl chloride (124-63-0) + but-3-yn-2-ol (2028-63-9) → 1-methylprop-2-ynyl methanesulfonate (59967-06-5)

Conditions	Yield
With triethylamine In dichloromethane for 1h; Ambient temperature;	100%
With triethylamine In dichloromethane at 0℃; for 3h; Inert atmosphere;	95%
With triethylamine In dichloromethane at 0℃; for 0.25h;	93%

but-3-yn-2-ol (2028-63-9) + tert-butylchlorodiphenylsilane (58479-61-1) → tert-butyl-(1-methyl-prop-2-ynyloxy)diphenylsilane (247923-45-1)

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 12h;	100%
With dmap; triethylamine In tetrahydrofuran at 20℃; for 18h; Inert atmosphere;	94%
With 1H-imidazole In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;	83%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;
With 1H-imidazole In dichloromethane at 0 - 20℃; for 8h;

4-tolyl iodide (624-31-7) + but-3-yn-2-ol (2028-63-9) → 4-(4-methylphenyl)but-3-yn-2-ol (79756-90-4)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 5.5h; Sonogashira coupling; Inert atmosphere;	100%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In dimethyl sulfoxide; triethylamine at 40 - 45℃; for 10.3h;	91%
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 7h; Sonogashira coupling;	87%

benzaldehyde (100-52-7) + but-3-yn-2-ol (2028-63-9) → 1-phenyl-2-pentyne-1,4-diol (135468-12-1)

Conditions	Yield
Stage #1: but-3-yn-2-ol With methyllithium In tetrahydrofuran; diethyl ether at -50℃; for 2h; Stage #2: benzaldehyde In tetrahydrofuran; diethyl ether at -50 - 20℃;	100%
Stage #1: but-3-yn-2-ol With n-butyllithium In tetrahydrofuran at -78℃; for 2h; Stage #2: benzaldehyde In tetrahydrofuran at -78 - 20℃; Further stages.;	82%
Stage #1: but-3-yn-2-ol With n-butyllithium In diethyl ether at -78℃; for 2h; Inert atmosphere; Stage #2: benzaldehyde In diethyl ether at -78 - 20℃; Inert atmosphere;	82%
With n-butyllithium In tetrahydrofuran at -78 - 20℃;
Stage #1: but-3-yn-2-ol With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Schlenk technique; Stage #2: benzaldehyde In tetrahydrofuran; hexane at -78 - 20℃; for 24h; Schlenk technique;

triisopropylsilyl chloride (13154-24-0) + but-3-yn-2-ol (2028-63-9) → 3-(triisopropylsilyl)oxybut-1-yne (868764-60-7)

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 15h;	100%

3,5-dimethylphenyl iodide (22445-41-6) + but-3-yn-2-ol (2028-63-9) → 4-(3,5-dimethylphenyl)-3-butyn-2-ol (1020212-00-3)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 4h; Sonogashira coupling; Inert atmosphere;	100%
With triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 100℃; for 0.166667h; Sonogashira reaction; microwave irradiation;

[κ1(C(1),C(4))-C(CO2Me)=C(CO2Me)C(CO2Me)=C(CO2Me)](PPh3)2IrCl + but-3-yn-2-ol (2028-63-9) → [κ1(C(1),C(4))-C(CO2Me)=C(CO2Me)C(CO2Me)=C(CO2Me)](PPh3)2Ir(CO)(E-CH=CHMe) (167385-31-1)

Conditions	Yield
In dichloromethane; water two phases, 24 h at 25°C;	100%
In chloroform; water in air, Ir compd. and ligand (1:10 molar ratio) in aq. chloroform, stirred at 23°C for 15 h; evapd., recrystd. (benzene/hexane);	95%
In dichloromethane-d2; water Ir compd. and ligand for 21 h; NMR;

1,4-diazidobutane (24345-72-0) + but-3-yn-2-ol (2028-63-9) → C12H20N6O2 (1250839-21-4)

Conditions	Yield
With copper(I) bromide In N,N-dimethyl-formamide at 50℃; for 12h; Huigen-type cycloaddition; regioselective reaction;	100%

C23H26I2O4 + but-3-yn-2-ol (2028-63-9) → C31H36O6

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran Sonogashira Cross-Coupling;	100%

but-3-yn-2-ol (2028-63-9) + chlorophosphoric acid diphenyl ester (2524-64-3) → but-3-yn-2-yl diphenyl phosphate

Conditions	Yield
With triethylamine; trifluoroacetic acid In dichloromethane at 0 - 20℃; Inert atmosphere;	100%

but-3-yn-2-ol (2028-63-9) + Diphenylphosphinic chloride (1499-21-4) → O-1-methyl-2-propynyl phenylphenylphosphinate (23834-42-6)

Conditions	Yield
With triethylamine; trifluoroacetic acid In dichloromethane at 0 - 20℃; Inert atmosphere;	100%

benzophenone (119-61-9) + but-3-yn-2-ol (2028-63-9) → (R/S)-1,1-diphenylpent-2-yne-1,4-diol (783339-46-8)

Conditions	Yield
Stage #1: but-3-yn-2-ol With n-butyllithium In tetrahydrofuran; hexane at -40℃; for 0.333333h; Inert atmosphere; Stage #2: benzophenone With cerium(III) chloride In tetrahydrofuran; hexane Reagent/catalyst;	100%
Stage #1: but-3-yn-2-ol With n-butyllithium In tetrahydrofuran; hexane at -40℃; for 0.5h; Inert atmosphere; Stage #2: benzophenone In tetrahydrofuran; hexane Inert atmosphere;	87%

ethyl vinyl ether (109-92-2) + but-3-yn-2-ol (2028-63-9) → 2-(3-oxa-pent-2-yloxy)-but-3-yne (5967-11-3)

Conditions	Yield
With pyridinium p-toluenesulfonate In dichloromethane at 23℃; for 1h;	99%
With pyridinium p-toluenesulfonate In dichloromethane at 23℃; for 1h;	99%
With pyridinium p-toluenesulfonate In dichloromethane for 1h;	93%
With hydrogenchloride for 2h;	83%
With hydrogenchloride

but-3-yn-2-ol (2028-63-9) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 3-(trimethylsiloxy)but-1-yne (17869-76-0, 100244-12-0, 117924-32-0)

Conditions	Yield
at 110℃; for 12h;	99%
at 110℃; for 16h;	99%
for 0.166667h; microwave irradiation;	95%

dicobalt octacarbonyl (15226-74-1, 61091-28-9, 61117-58-6) + but-3-yn-2-ol (2028-63-9) → (μ-η(2)-η(2)-HC*CCH(CH3)OH)Co2(CO)6 (40687-04-5, 172511-75-0)

Conditions	Yield
In dichloromethane at 20℃; Inert atmosphere;	99%
In diethyl ether N2; soln. stirred for 0.5 h until no CO evolution was no longer visible; evapn., flash chromy. (elution with hexane to remove Co impurities); elution with 20/1 hexane/ethylacetate, elem. anal.;	84%
In not given reacting Co2(CO)8 soln. with alkyne until CO formation is completed; room temp., under N2;
In not given reacting Co2(CO)8 soln. with alkyne until CO formation is completed; room temp., under N2;

ethane-1,2-diyl bis(2-(2-iodophenyl)acetate) (1269806-61-2) + but-3-yn-2-ol (2028-63-9) → ethane-1,2-diyl bis(2-(2-(3-hydroxybut-1-ynyl)phenyl)acetate) (1269806-66-7)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran Sonogashira coupling;	99%

butane-1,4-diyl bis(2-(2-iodophenyl)acetate) (1269806-62-3) + but-3-yn-2-ol (2028-63-9) → butane-1,2-diyl bis(2-(2-(3-hydroxybut-1-ynyl)phenyl)acetate) (1269806-71-4)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran Sonogashira coupling;	99%

thiophenol (108-98-5) + but-3-yn-2-ol (2028-63-9) → 3-phenylsulfanyl-butan-2-one (13023-53-5, 132187-18-9, 132187-19-0)

Conditions	Yield
Stage #1: but-3-yn-2-ol With palladium diacetate; gold(I) chloride In nitromethane at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: thiophenol In nitromethane at 80℃; for 8h; Solvent; Time; Inert atmosphere; regioselective reaction;	99%

thiophenol (108-98-5) + but-3-yn-2-ol (2028-63-9) → 3-(phenylthio)-3-buten-2-ol (77202-27-8)

Conditions	Yield
Stage #1: but-3-yn-2-ol With palladium diacetate; gold(I) chloride In nitromethane at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: thiophenol In nitromethane at 60℃; for 3h; Inert atmosphere; regioselective reaction;	99%
Stage #1: but-3-yn-2-ol With palladium diacetate In nitromethane at 20℃; for 0.0833333h; Microwave irradiation; Sealed tube; Stage #2: thiophenol In nitromethane at 80℃; for 16h; regioselective reaction;	51%

cyclohexyl azide (19573-22-9) + but-3-yn-2-ol (2028-63-9) → 1-cyclohexyl-4-(1-hydroxyethyl)-1,2,3-triazole

Conditions	Yield
With 2-{4-[(dimethylamino)methyl]-1,2,3-triazol-1-yl}cyclohexan-1-ol; copper(II) sulfate; sodium L-ascorbate In ethanol; water at 20℃; for 1.5h; Reagent/catalyst; Huisgen Cycloaddition;	99%
With 2-{4-[(dimethylamino)methyl]-1,2,3-triazolyl}cyclohexan-1-ol; copper(II) sulfate; sodium L-ascorbate In ethanol; water at 20℃; for 1.5h;	99%

BOC-glycine (4530-20-5) + but-3-yn-2-ol (2028-63-9) → N-Boc-glycine-2-butyn-1-ester (537710-07-9)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Inert atmosphere;	99%

1-Iodonaphthalene (90-14-2) + but-3-yn-2-ol (2028-63-9) → 4-(naphthalen-1-yl)but-3-yn-2-ol

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 0 - 20℃; for 16h; Sonogashira Cross-Coupling; Inert atmosphere;	99%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	98%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 20℃;

Phenylselenyl bromide (34837-55-3) + but-3-yn-2-ol (2028-63-9) → 4-Phenylselanyl-but-3-yn-2-ol (104829-02-9)

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h;	98%

1-Fluoro-2-iodobenzene (348-52-7) + but-3-yn-2-ol (2028-63-9) → 4-(2-fluorophenyl)but-3-yn-2-ol (893746-80-0)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	98%
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide at 60℃;

but-3-yn-2-ol (2028-63-9) + para-nitrophenyl bromide (586-78-7) → 4-(4'-nitrophenyl)-3-butyn-2-ol (111887-20-8)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 80℃; Inert atmosphere; Schlenk technique;	98%
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide at 80℃;

2-Iodothiophene (3437-95-4) + but-3-yn-2-ol (2028-63-9) → (+/-)-4-(thiophen-2-yl)but-3-yn-2-ol (422308-84-7)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	98%
With copper(l) iodide; ethanolamine; triphenylphosphine; palladium on activated charcoal In water at 80℃; for 8h; Sonogashira coupling;	90%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 60℃; Inert atmosphere; Schlenk technique;	84%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 20℃;
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 12h;

(Z)-{N-[4-(2-(N'-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-4-methylbenzenesulfonamido)methylallyloxy]but-2-enyl}-2-nitrobenzenesulfonamide (1018387-42-2) + but-3-yn-2-ol (2028-63-9) → C35H32F17N3O7S2 (1018389-92-8)

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 1h; Fukuyama-Mitsunobu reaction;	98%

3-Iodotoluene (625-95-6) + but-3-yn-2-ol (2028-63-9) → 4-(m-methylphenyl)-3-butyn-2-ol (265660-98-8)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	98%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In dimethyl sulfoxide; triethylamine at 40 - 45℃; for 10.5h;	89%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 20℃;
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 12h;

Upstream product

• 1423-60-5 methyl ethynyl ketone 
• 3913-65-3 2-hydroxypropanal 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 103253-60-7 4-trimethylsilyl-3-butyn-2-ol 
• 75-07-0 acetaldehyde 
• 4301-14-8 acetylenemagnesium bromide 
• 70277-75-7 lithium acetylide 
• 846539-19-3 trimethyl(4-{[(1-methylprop-2-yn-1-yl)oxy]methyl}benzyl)silane 
• 198014-16-3 3-bromo-3-buten-2-ol 
• 925-90-6 ethylmagnesium bromide 
• 74-86-2 acetylene 
• 60-29-7 diethyl ether 
• 1066-26-8 sodium acetylide 
• 4301-15-9 ethynyldimagnesium dibromide 

Downstream Products

• 10575-26-5 1-diethylamino-pent-2-yn-4-ol 
• 42969-62-0 (+/-)-but-3'-yn-2'-yl hydrogen phthalate 
• 256510-24-4 2-Amino-benzoic acid 1-methyl-prop-2-ynyl ester 
• 30197-13-8 (Z)-3-Hydroxy-1-phenylseleno-1-butene 
• 104828-94-6 3-phenylselanylbut-3-en-2-ol 
• 41437-85-8 (E)-4-cyclohex-1-enyl-but-3-en-2-one 
• 127938-91-4 2-(buta-1,2-dienyl)-2-methylcyclohexanone 
• 41641-07-0 1-(3-hydroxy-1-butynyl)-2-methylcyclohexanol 
• 161584-32-3 1-methylpropargyl p-chlorobenzenesulphonate 
• 55136-85-1 (buta-1,2-dienylsulfonyl)benzene 
• 2028-63-9 (+)-but-3-yn-2-ol 
• 2028-63-9 (-)-but-3-yn-2-ol 
• 91-55-4 2,3-dimethylindole 

Relevant articles and documents

Method for synthesizing 3 -butyne -2 - alcohol with high yield

The invention discloses a method for synthesizing 3 -butyne -2 - alcohol, wherein tripolyacetaldehyde is used as a raw material acetaldehyde source, and potassium hydroxide or potassium tert-butoxide or potassium tert-butoxide is used as a dispersant. After the reaction endpoint material is hydrolyzed to remove potassium hydroxide, the target product 3 - butyne -2 - alcohol is separated by aqueous phase extraction. The method has the advantages of low acetylene reaction pressure. Target product yield is high.

Phosphine-Catalyzed Intermolecular Annulations of Fluorinated ortho-Aminophenones with Alkynones – The Switchable [4+2] or [4+2]/[3+2] Cycloaddition

A phosphine-catalyzed intermolecular annulation reaction of functionalized ortho-aminoacetophenones with alkynones has been disclosed in this paper. A variety of 2-alkynylquinolines and benzo-fused indolizine were selectively afforded in moderate to good yields at different reaction temperatures and with different phosphine catalysts via the in situ generated zwitterionic intermediate derived from alkynone and phosphine. (Figure presented.).

Gold(I)-catalyzed decarboxylation of propargyl carbonates: Reactivity reversal of the gold catalyst from π-Lewis acidity to σ-Lewis acidity

A cationic gold(I)-catalyzed decarboxylative etherification of propargyl carbonates to selectively produce propargyl ethers is reported. In the reaction the gold(I) catalyst shows a distinct σ-Lewis acidity rather than the commonly observed π-Lewis acidity, and thus catalyzes the decarboxylation of a variety of propargyl carbonates to give the corresponding propargyl ethers with high selectivity. This reaction represents a rare example of the tunable reactivity of cationic gold(I) complexes between σ-Lewis acidity and π-Lewis acidity.