17260-67-2

Basic information

• Product Name: 2-Chloro-N-methylbenzenesulphonamide
• Synonyms: 2-Chloro-N-methylbenzenesulphonamide;2-chloro-N-methylbenzenesulfonamide
• CAS NO: 17260-67-2
• Molecular Formula: C₇H₈ClNO₂S
• Molecular Weight: 205.66192
• Mol File: 17260-67-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 94-96
• Boiling Point: 321.323 °C at 760 mmHg
• Flash Point: 148.131 °C
• Appearance: /
• Density: 1.353 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Chloro-N-methylbenzenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-methylbenzenesulphonamide(17260-67-2)
• EPA Substance Registry System: 2-Chloro-N-methylbenzenesulphonamide(17260-67-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 17260-67-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-N-methylbenzenesulphonamide is a chemical compound with the molecular formula C7H8ClNO2S. It is a sulphonamide derivative and is commonly used as an antimicrobial agent in various industrial and medical applications. 2-Chloro-N-methylbenzenesulphonamide is white to off-white in color and is known for its water-soluble properties. It is also utilized in the manufacturing of pharmaceuticals and as a preservative in various products. Additionally, 2-Chloro-N-methylbenzenesulphonamide is used in the production of dyes and as a solubilizing agent in the synthesis of other chemicals.

InChI:InChI=1/C7H8ClNO2S/c1-9-12(10,11)7-5-3-2-4-6(7)8/h2-5,9H,1H3

Upstream product

• 67-56-1 methanol 
• 6961-82-6 2-chlorobenzenesulfonamide 
• 74-89-5 methylamine 
• 2905-23-9 2-chlorophenylsulfonyl chloride 

Relevant articles and documents

Recyclable covalent triazine framework-supported iridium catalyst for the N-methylation of amines with methanol in the presence of carbonate

An iridium complex Cp*Ir@CTF, which is synthesized by the coordinative immobilization of [Cp*IrCl2]2 on a functionalized covalent triazine framework (CTF), was found to be a general and highly efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate. Under environmentally benign conditions, a variety of desirable products were obtained in high yields with complete selectivities and functional group friendliness. Furthermore, the synthesized catalyst could be recycled by simple filtration without obvious loss of catalytic activity after sixth cycle. Notably, this research exhibited the potential of covalent triazine framework-supported transition metal catalysts for hydrogen autotransfer process.

N-Methylation of Amines with Methanol in Aqueous Solution Catalyzed by a Water-Soluble Metal-Ligand Bifunctional Dinuclear Iridium Catalyst

The N-methylation of amines with methanol in aqueous solution was proposed and accomplished by using a water-soluble metal-ligand bifunctional dinuclear iridium catalyst. In the presence of [(Cp*IrCl)2(thbpym)][Cl]2 (1 mol %), a range of desirable products were obtained in high yields under environmentally benign conditions. Notably, this research exhibited the potential of transition metal-catalyzed activation of methanol as a C1 source for the construction of the C-N bond in aqueous solution.

TACHYKININ RECEPTOR ANTAGONISTS

The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.