172734-63-3Relevant articles and documents
Investigation of SAR requirements of SR 142801 through an indexed combinatorial library in solution
Raveglia, Luca F.,Vitali, Mauro,Artico, Marco,Graziani, Davide,Hay, Douglas W.P.,Luttmann, Mark A.,Mena, Renzo,Pifferi, Giorgio,Giardina, Giuseppe A.M.
, p. 825 - 835 (2007/10/03)
To rapidly gain information on structure-activity relationship (SAR) requirements of the human neurokinin 3 (hNK-3) receptor antagonist SR 142801, an indexed combinatorial library was synthesised in solution and screened on the hNK-3 receptor. SAR considerations drawn from binding affinity of combinatorial mixtures were confirmed through the synthesis and biological evaluation of some individual compounds.