182621-51-8

Basic information

• Product Name: 3-(3-(3,4-DICHLOROPHENYL)PIPERIDIN-3-YL)PROPAN-1-OL
• Synonyms: 3-(3-(3,4-DICHLOROPHENYL)PIPERIDIN-3-YL)PROPAN-1-OL;3-Piperidinepropanol, 3-(3,4-dichlorophenyl)-
• CAS NO: 182621-51-8
• Molecular Formula: C₁₄H₁₉Cl₂NO
• Molecular Weight: 288.216
• Mol File: 182621-51-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 412.448 °C at 760 mmHg
• Flash Point: 203.241 °C
• Appearance: /
• Density: 1.197
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.545
• PKA: 15.16±0.10(Predicted)
• CAS DataBase Reference: 3-(3-(3,4-DICHLOROPHENYL)PIPERIDIN-3-YL)PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-(3,4-DICHLOROPHENYL)PIPERIDIN-3-YL)PROPAN-1-OL(182621-51-8)
• EPA Substance Registry System: 3-(3-(3,4-DICHLOROPHENYL)PIPERIDIN-3-YL)PROPAN-1-OL(182621-51-8)

Safety Data

• Hazardous Substances Data: 182621-51-8(Hazardous Substances Data)

Usage

General Description

The chemical compound 3-(3-(3,4-Dichlorophenyl)piperidin-3-yl)propan-1-ol is a complex organic molecule that features core elements of carbon, hydrogen, chlorine, nitrogen and oxygen. Its structural composition includes a piperidine ring, a common feature in numerous pharmaceuticals, and a dichlorophenyl group that contributes to the molecule's properties. As with any compound, its properties and interactions can vary greatly depending on its associations and environment. Currently, there isn't a wealth of specific data or applications connected to this exact chemical, therefore potential uses, risk factors, or roles in industrial or scientific contexts may still be for detailed study and examination.

InChI:InChI=1/C14H19Cl2NO/c15-12-4-3-11(9-13(12)16)14(6-2-8-18)5-1-7-17-10-14/h3-4,9,17-18H,1-2,5-8,10H2

Upstream product

• 182621-49-4 4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid 
• 146395-96-2 2-(3,4-dichloro-phenyl)-5-(tetrahydro-pyran-2-yl-oxy)-pentanenitrile 
• 146395-97-3 4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid ethyl ester 
• 146395-98-4 5-tetrahydropyranyloxypropyl-5-(3,4-dichlorophenyl)piperidone 
• 182621-50-7 Acetic acid 3-[3-(3,4-dichloro-phenyl)-2,6-dioxo-piperidin-3-yl]-propyl ester 
• 146395-99-5 3-(3,4-Dichloro-phenyl)-3-[3-(tetrahydro-pyran-2-yloxy)-propyl]-piperidine 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 

Downstream Products

• 172734-92-8 osanetant 
• 146396-03-4 1-benzoyl-3-(3,4-dichlorophenyl)-3-(3-methane-sulphonyloxypropyl)piperidine 
• 182621-57-4 {3-(3,4-Dichloro-phenyl)-3-[3-(4-methylamino-4-phenyl-piperidin-1-yl)-propyl]-piperidin-1-yl}-phenyl-methanone 
• 172734-92-8 (S)-(N)-(1-(3-(1-benzoyl-3(3,4-dichlorophenyl)piperidin-3-yl)propyl)-4-phenylpiperidin-4-yl)-N-methylacetamide 
• 256497-28-6 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(1-phenyl-1,3,8-triazaspiro[4.5]decan-4-on-8-yl)propyl]piperidine 
• 256497-29-7 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-{3-[4-(pyrrolidinocarbonylmethyl)piperazin-1-yl]propyl}piperidine 
• 256497-24-2 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-phenylpiperazin-1-yl)propyl]piperidine 
• 256497-23-1 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-phenylpiperidin-1-yl)propyl]piperidine 
• 256497-27-5 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]piperidine 
• 256497-25-3 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-isopropylpiperazin-1-yl)propyl]piperidine 
• 256497-26-4 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(morpholin-4-yl)propyl]piperidine 
• 172734-63-3 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-(3-methanesulfonyloxypropyl)piperidine 

Relevant articles and documents

3-alkyl-3-phenyl-piperidines

PCT No. PCT/US97/15443 Sec. 371 Date Jan. 22, 1998 Sec. 102(e) Date Jan. 22, 1998 PCT Filed Sep. 2, 1997 PCT Pub. No. WO98/11090 PCT Pub. Date Mar. 19, 1998The small nonpeptides of the instant invention are tachykinin antagonists of formula or a pharmaceutically acceptable salt thereof wherein: R1 is straight or branched alkyl of from 5 to 15 carbon atoms, aryl, or heteroaryl; R2 is hydrogen, hydroxy, amino, or thiol; R3 is aryl, arylsulfonylmethyl, or saturated or unsaturated heterocycle; R4 is from 1 to 4 groups each independently selected from halogen, alkyl, hydroxy, and alkoxy; n is an integer of from 2 to 6; and the carbon atom of (CH2)n group can be replaced by oxygen, nitrogen, or sulphur. The compounds are highly selective and functional NK3 antagonists expected to be useful in the treatment of pain, depression, anxiety, panic, schizophrenia, neuralgia, addiction disorders, inflammatory diseases, gastrointestinal disorders, vascular disorders, and neuropathological disorders.

A reliable and efficient synthesis of SR 142801

A convenient synthesis of the potent human NK-3 receptor antagonist SR 142801, (S)-(+)-N-{{3-[1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1 -yl}-4-phenylpiperidin-4-yl}-N-methylacetamide [(S)-(+)-(15)], is described. Improvements over the previously reported procedure are the preparation of the intermediate 5 via the novel imide 3 and subsequent reaction with the nucleophile 14, which reacts, regioselectively, at the endocyclic nitrogen.