173544-50-8Relevant articles and documents
1,3-Dioxolobenzodiazepines
Gakhar, H. K.,Sangar, Neeraj,Aggarwal, Sheetal,Arora, G. S.
, p. 1089 - 1091 (2007/10/03)
Some 5,8-disubstituted-5,6,7,8-tetrahydro-9H-1,3-dioxolobenzodiazepines (6a-c) have been synthesised by the reduction of 2-amino>ethanol/isopropanol (3a/b) with tin and HCl, followed by treatment of the resultant 2-amino>ethanol/isopropanol (4a/b) with methanesulphonyl chloride/p-toluenesulphonyl chloride and subsequent cyclisation of the intermediates (5a-c), thus formed, with sodium ethoxide.Compounds 3a-c required for this purpose have been prepared by the reaction of 6-nitropiperonyl chloride (1) with 2-aminoethanol/1-amino-2-propanol (2a/b).Structures of the various compounds prepared have been confirmed on the basis of 1H NMR data and elemental analyses.