173901-02-5

Basic information

• Product Name: Benzenesulfonyl chloride, 4-[[(hexylamino)carbonyl]amino]-
• CAS NO: 173901-02-5
• Molecular Formula: C13H19ClN2O3S
• Molecular Weight: 318.824
• Mol File: 173901-02-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenesulfonyl chloride, 4-[[(hexylamino)carbonyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonyl chloride, 4-[[(hexylamino)carbonyl]amino]-(173901-02-5)
• EPA Substance Registry System: Benzenesulfonyl chloride, 4-[[(hexylamino)carbonyl]amino]-(173901-02-5)

Safety Data

• Hazardous Substances Data: 173901-02-5(Hazardous Substances Data)

Upstream product

• 106-32-1 octanoic acid ethyl ester 
• 1142-07-0 1-n-hexyl-3-phenyl-urea 
• 111-26-2 hexan-1-amine 
• 103-71-9 phenyl isocyanate 
• 6752-38-1 4-chlorosulfonylbenzene isocyanate 
• 62-53-3 aniline 

Downstream Products

• 173901-20-7 (2-{4-[4-(3-Hexyl-ureido)-benzenesulfonylamino]-phenyl}-ethyl)-((R)-2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester 
• 241467-59-4 1-{4'-[4-(3-hexyl-ureido)-benzenesulfonylamino]-biphenyl-4-yloxymethyl}-6,7-dihydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 241467-61-8 N-[2-(3,4-bis-benzyloxy-phenyl)-ethyl]-2-{6-[4-(3-hexyl-ureido)-benzenesulfonylamino]-naphthalen-2-yloxy}-acetamide 
• 373359-54-7 4-(3-hexylureido)-N-[4-(4-oxopiperidin-1-yl)phenyl]benzenesulfonamide 
• 1190615-53-2 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(pyridin-3-yl)methyl]-5-(4-{[(4-{[(hexylamino)carbonyl]amino}phenyl)sulfonyl]amino}benzyl)pyrrolidine-1-carboxylate trifluoroacetate 
• 1190614-46-0 4-{[(hexylamino)carbonyl]amino}-N-[4-({(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl}methyl)phenyl]benzenesulfonamide trifluoroacetate 

Relevant articles and documents

HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS

The present invention provides compounds of Formula I, pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

Novel substituted 4-aminomethylpiperidines as potent and selective human β3-agonists. Part 1: Aryloxypropanolaminomethylpiperidines

The synthesis and SAR of a series of human β3 adrenoreceptor agonists based on a template derived from a common pharmacophore coupled with 4-aminomethylpiperidine is described. Potent and selective agents were identified such as 26 that was in vitro active in CHO cells expressing human β3-AR (EC50=49 nM, IA=1.1), and in vivo active in a transgenic mouse model.

SUBSTITUTED SULFONAMIDES AS SELECTIVE BETA3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

Substituted sulfonamides are selective β 3 adrenergic receptor agonists with very little β 1 and β 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent