241467-59-4

Basic information

• Product Name: 1-{4'-[4-(3-hexyl-ureido)-benzenesulfonylamino]-biphenyl-4-yloxymethyl}-6,7-dihydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
• CAS NO: 241467-59-4
• Molecular Weight: 744.909
• Mol File: 241467-59-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-{4'-[4-(3-hexyl-ureido)-benzenesulfonylamino]-biphenyl-4-yloxymethyl}-6,7-dihydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{4'-[4-(3-hexyl-ureido)-benzenesulfonylamino]-biphenyl-4-yloxymethyl}-6,7-dihydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(241467-59-4)
• EPA Substance Registry System: 1-{4'-[4-(3-hexyl-ureido)-benzenesulfonylamino]-biphenyl-4-yloxymethyl}-6,7-dihydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(241467-59-4)

Safety Data

• Hazardous Substances Data: 241467-59-4(Hazardous Substances Data)

Upstream product

• 241467-58-3 2-[(1,1-Dimethylethoxy)carbonyl]-1-[[4'-nitro-(1,1'-biphenyl)-4-yloxy]methyl]-6,7-bis(phenylmethoxy)-1,2,3,4-tetrahydroisoquinoline 
• 171364-83-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene 
• 173901-02-5 4-[[(hexylamino)carbonyl]-amino]benzenesulfonyl chloride 

Relevant articles and documents

Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human β3 adrenergic receptor agonists

Tetrahydroisoquinoline derivatives containing a 4-(hexylureido)benzenesulfonamide were examined as human β3 adrenergic receptor (AR) agonists. Notably, 4,4-biphenyl derivative 9 was a 6 nM full agonist of the β3 AR. Naphthyloxy compound 18 (β3 EC50 = 78 nM) did not activate the β1 and β2 ARs at 10 μM, and showed >1000-fold selectivity over binding to the β1 and β2 ARs. (C) 2000 Elsevier Science Ltd.