174309-28-5

Basic information

• Product Name: 2,4-diethyl (2R,4S)-1-benzylazetidine-2,4-dicarboxylate
• CAS NO: 174309-28-5
• Molecular Weight: 291.347
• Mol File: 174309-28-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2,4-diethyl (2R,4S)-1-benzylazetidine-2,4-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-diethyl (2R,4S)-1-benzylazetidine-2,4-dicarboxylate(174309-28-5)
• EPA Substance Registry System: 2,4-diethyl (2R,4S)-1-benzylazetidine-2,4-dicarboxylate(174309-28-5)

Safety Data

• Hazardous Substances Data: 174309-28-5(Hazardous Substances Data)

Usage

General Description

2,4-diethyl (2R,4S)-1-benzylazetidine-2,4-dicarboxylate is a chemical compound with the molecular formula C17H23NO4. It is an azetidine derivative that contains a benzyl group and two ethyl groups attached to a diester of azetidine dicarboxylic acid. 2,4-diethyl (2R,4S)-1-benzylazetidine-2,4-dicarboxylate is often used in chemical and pharmaceutical research, and its specific properties and potential uses are under ongoing investigation. The structure of 2,4-diethyl (2R,4S)-1-benzylazetidine-2,4-dicarboxylate makes it an interesting target for studying the reactivity and biological activity of azetidine derivatives.

Upstream product

• 96960-31-5 meso-α,α'-dibromoglutaric anhydride 
• 108-55-4 glutaric anhydride, 
• 116652-68-7 1,5-diethyl (2R,4S)-2,4-dibromopentanedioate 
• 100-46-9 benzylamine 
• 870-78-0 2,4-dibromoglutaric acid diethyl ester 
• 2873-74-7 gloutaric dichloride 

Downstream Products

• 1414860-35-7 tert-butyl 3-oxa-6-azabicyclo[3.1.1]heptane-1-carboxylate 
• 1414860-36-8 3-oxa-6-azabicyclo[3.1.1]heptane 4-methylbenzenesulfonate 
• 1414540-31-0 1-tert-butyl 2,4-diethyl cis-azetidine-1,2,4-tricarboxylate 
• 1414540-38-7 tert-butyl (cis)-2,4-bis{[(4-methylbenzenesulfonyl)oxy]methyl}azetidine-1-carboxylate 
• 1414540-41-2 tert-butyl 3-[(2-nitrophenyl)sulfonyl]-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate 
• 869494-16-6 3,6-diazabicyclo[3.1.1]heptane-6-carboxylic acid tert-butyl ester 
• 1414540-46-7 3-[(2-nitrophenyl)sulfonyl]-3,6-diazabicyclo[3.1.1]heptane 
• 351075-70-2 (2R,4S)-2-(acetoxymethyl)-1-benzyl-4-{[(t-butyldimethyl)silyloxy]methyl}azetidine 
• 351075-63-3 (2R,4R)-1-(t-butoxycarbonyl)-α,α-diphenyl-4-methylazetidine-2-methanol 
• 351075-50-8 (2R,4S)-1-benzyl-4-{[(t-butyldimethyl)silyloxy]methyl}azetidine-2-methanol 
• 351075-59-7 (2R,4S)-2-(acetoxymethyl)-1-benzyl-4-(methanesulfonyloxy)methylazetidine 
• 351075-49-5 (2S,4R)-4-acetoxymethyl-1-benzylazetidine-2-methanol 
• 351075-64-4 (2R,4R)-α,α-diphenyl-4-methylazetidine-2-methanol 
• 351075-60-0 (2R,4R)-1-benzyl-4-methylazetidine-2-methanol 

Relevant articles and documents

SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY

The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

Concise synthesis of N3- and N6-monoprotected 3,6-diazabicyclo[3.1.1]heptanes; Useful intermediates for the preparation of novel bridged bicyclic piperazines

Bridged bicyclic piperazines are important building blocks in medicinal chemistry research. The bicyclic piperazine 3,6-diazabicylo[3.1.1]heptane is of particular interest as a piperazine isostere because it is achiral and shows similar lipophilicity to that of piperazine based on the c Log P of a derived analog. A concise synthesis of N3- and N6-monoprotected 3,6-diazabicyclo[3.1.1]heptanes 2d and 2e, respectively, is described. The seven step sequence begins with inexpensive starting materials and uses straightforward chemistry.

Synthesis of Optically Active N-Benzyl-2,4-Bis(hydroxymethyl) Substituted Azetidines by Lipase Catalyzed Acetylations

Both cis- and trans-N-benzyl-azetidine-2,4-dimethanols 5 and 6 were prepared and submitted to acetylation in organic solvents catalyzed by lipases.Asymmetrization of diol 5 gave the corresponding monoacetate 7, while double sequential kinetic resolution of racemic 6 gave optically enriched diol 6b and its enantiomer as the corresponding diacetate 10a.Optimized reaction conditions furnished 7, 6b and 10a with e.e.>99percent.