17460-56-9

Basic information

• Product Name: Z-D-PHE-PRO-OH
• Synonyms: Z-PHENYLALANINE-D-PROLINE;Z-D-PHE-PRO-OH;(S)-1-((R)-2-(benzyloxycarbonylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxylic acid;CBZ-D-Phe-Pro-OH;N-Benzyloxycarbonyl-D-phenylalanlyproline
• CAS NO: 17460-56-9
• Molecular Formula: C₂₂H₂₄N₂O₅
• Molecular Weight: 396.44
• Mol File: 17460-56-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 132-133 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 669.586 °C at 760 mmHg
• Flash Point: 358.753 °C
• Appearance: /
• Density: 1.292 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: -15°C
• PKA: 3.51±0.20(Predicted)
• CAS DataBase Reference: Z-D-PHE-PRO-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-D-PHE-PRO-OH(17460-56-9)
• EPA Substance Registry System: Z-D-PHE-PRO-OH(17460-56-9)

Safety Data

• Hazardous Substances Data: 17460-56-9(Hazardous Substances Data)

Usage

General Description

Z-D-Phe-Pro-OH is a chemical compound that consists of the amino acids phenylalanine and proline, as well as a carboxylic acid group. It is a dipeptide, meaning it is made of two amino acids joined together by a peptide bond. Z-D-PHE-PRO-OH is commonly used in biochemical and pharmaceutical research as a model system to study the structure and function of peptides. It has also been used in the development of pharmaceutical drugs and as a building block in the synthesis of larger peptides and proteins. Overall, Z-D-Phe-Pro-OH plays an important role in the study and development of bioactive compounds and has potential applications in medicine and biotechnology.

InChI:InChI=1/C22H24N2O5/c25-20(24-13-7-12-19(24)21(26)27)18(14-16-8-3-1-4-9-16)23-22(28)29-15-17-10-5-2-6-11-17/h1-6,8-11,18-19H,7,12-15H2,(H,23,28)(H,26,27)/t18-,19+/m1/s1

Upstream product

• 147-85-3 L-proline 
• 2812-46-6 proline tert-butyl ester 
• 2448-45-5 Cbz-D-Phe 
• 870695-98-0 benzyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 2448-45-5 N-(Benzyloxycarbonyl)-D-phenylalanine 
• 63358-25-8 Z-D-Phe-OTCP 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 41518-17-6 Z-Phe-O-COO-isoBu 
• 1161-13-3 N-Cbz-L-Phe 
• 501-53-1 benzyl chloroformate 
• 175446-63-6 proline acid chloride 
• 63-91-2 L-phenylalanine 
• 769922-77-2 (S)-benzyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 17543-49-6 (S)-benzyloxycarbonylphenylalanine pentafluorophenyl ester 

Downstream Products

• 132370-19-5 H-Tyr-Pro-Phe-Pro-Gly-EtDA<*>Gly-H 
• 132370-20-8 H-Tyr-Pro-Phe-Pro-Gly-EtDA<*>Gly<*>Gly-H 
• 161403-94-7 H-Phe-Pro-Gly-EtDA<*>Gly-Boc 
• 161403-99-2 [({[2-(2-{[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-acetylamino)-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamic acid tert-butyl ester 
• 161403-93-6 Z-Phe-Pro-Gly-EtDA<*>Gly-Boc 
• 161404-00-8 Z-Pro-Phe-Pro-Gly-EtDA<*>Gly<*>Gly-Boc 
• 161403-95-8 Z-Tyr(Bzl)-Pro-Phe-Pro-Gly-EtDA<*>Gly-Boc 
• 161404-01-9 Z-Tyr(Bzl)-Pro-Phe-Pro-Gly-EtDA<*>Gly<*>Gly-Boc 
• 161404-03-1 Z-Tyr(Bzl)-Pro-Phe-Pro-Gly-EtDA<*>Gly<*>Gly-CO-(CH2)2-COOH 
• 139222-68-7 2-(N-benzyloxycarbonyl-L-phenylalanyl-L-prolyl-L-valyl)amino-6-methylbenzoic acid 
• 7531-52-4 L-prolinamide 
• 162990-46-7 Cbz-(R)-Phe-Pro-BoroMpg-OPinacol 
• 73871-00-8 Z-D-Phe-L-Pro-L-Val-OMe 

Relevant articles and documents

MALT1 INHIBITORS AND USES THEREOF

Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin' s lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis,an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).

A benzotriazole-mediated route to protected marine-derived hetero-2,5-diketopiperazines containing proline

A procedure for the cyclization of dipeptidoyl benzotriazolides containing proline derivatives promoted by triethylamine under MW activation is introduced. The reaction is general for a variety of dipeptidoyl benzotriazolides and represents a very practical and convenient method for the preparation of Pro- or Hyp-derived 2,5-diketopiperazines (2,5-DKPs) and bis-DKPs with a disulfide linker. This method can be used for the construction of 2,5-DKP compound libraries and for the synthesis of natural products with diketopiperazine cores. This journal is

Efficient peptide coupling involving sterically hindered amino acids

(Chemical Equation Presented) Hindered amino acids have been introduced into peptide chains by coupling N-(Cbz- and Fmoc-α-aminoacyl) benzotriazoles with amino acids, wherein at least one of the components was sterically hindered, to provide compounds 3a-e, (3c +3 c′), 5a-d, (5a + 5a′), 6a-c, (6b + 6b′), 8a-c, 9a-e, 10a-d, and (10a + 10a′) in isolated yields of 41-95% with complete retention of chirality as evidenced by NMR and HPLC analysis. The benzotriazole activation methodology is a new route for the synthesis of sterically hindered peptides. (Note: compound numbers written within brackets represent diastereomeric mixtures or racemates; compound numbers without brackets represent enantiomers.)