17515-80-9

Basic information

• Product Name: 5-(TRIFLUOROMETHYL)-2-FURALDEHYDE
• Synonyms: 5-(TRIFLUOROMETHYL)-2-FURALDEHYDE;5-(Trifluoromethyl)-2-furaldehyde 97%;5-(Trifluoromethyl)-2-furaldehyde97%;5-(Trifluoromethyl)furan-2-carbaldehyde;5-(Trifluoromethyl)furan-2-carboxaldehyde, 2-Formyl-5-(trifluoromethyl)furan, 5-(Trifluoromethyl)furfural;5-trifluoromethyl-2-furancarboxaldehyde
• CAS NO: 17515-80-9
• Molecular Formula: C₆H₃F₃O₂
• Molecular Weight: 164.08
• Mol File: 17515-80-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 184°Cat760mmHg
• Flash Point: 65.1°C
• Appearance: /
• Density: 1.397g/cm³
• Vapor Pressure: 4.47E-05mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(TRIFLUOROMETHYL)-2-FURALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(TRIFLUOROMETHYL)-2-FURALDEHYDE(17515-80-9)
• EPA Substance Registry System: 5-(TRIFLUOROMETHYL)-2-FURALDEHYDE(17515-80-9)

Safety Data

• Hazard Codes: T
• Statements: 25-36-43
• Safety Statements: 26-36/37-45
• Hazardous Substances Data: 17515-80-9(Hazardous Substances Data)

Usage

General Description

5-(Trifluoromethyl)-2-furaldehyde is a chemical compound with the molecular formula C7H4F3O2. It is a yellowish liquid with a fruity odor that is used as a chemical intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a flavor additive in food products. The compound is primarily synthesized through the reaction of 5-chloro-2-furaldehyde with trifluoromethyl magnesium bromide. It is known to be a potential irritant to the skin, eyes, and respiratory system, and precautions should be taken when handling or using this chemical.

InChI:InChI=1/C14H13BrO/c1-11-9-13(7-8-14(11)15)16-10-12-5-3-2-4-6-12/h2-9H,10H2,1H3

Upstream product

• 65865-28-3 (5-(trifluoromethyl)furan-2-yl)methanol 
• 56286-73-8 5-(trifluoromethyl)furan-2-carboxylic acid 
• 98-01-1 furfural 
• 901766-98-1 Trifluoro-acetic acid furan-2-yl-(2,2,2-trifluoro-acetoxy)-methyl ester 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 1383427-93-7 C₁₄H₂₂F₃NO₂Si 
• 936234-79-6 [(3S)-3-(N-benzyloxycarbonyl)amino-3-methoxycarbonylpropyl][(5-trifluoromethylfuran-2-yl)hydroxymethyl]phosphinic acid 
• 1314872-83-7 7,9-dimethyl-11-phenyl-6-(5-trifluoromethylfuran-2-yl)-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(7H,9H)-dione 
• 71160-09-3 2,6-dimethyl-4-(5-trifluoromethyl-furan-2-yl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 

Relevant articles and documents

Synthesis of trifluoromethyl-substituted heteroaromatic aldehydes

Trifluoromethylation of furfural and thiophene-2-carbaldehyde trifluoroacetates with XeF2 and CF3COOH afforded 5-trifluoromethylfuran-2-carbaldehyde and 5-trifluoromethylthiophene-2- carbaldehyde.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.