17825-15-9

Basic information

• Product Name: 7-BENZYLOXY-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ETHYL (7-BENZYLOXY-4-HYDROXY)QUINOLINE-3-CARBOXYLATE;7-BENZYLOXY-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS NO: 17825-15-9
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.34
• Mol File: 17825-15-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 491°C at 760 mmHg
• Flash Point: 250.8°C
• Appearance: /
• Density: 1.248g/cm³
• Vapor Pressure: 8.69E-10mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 7-BENZYLOXY-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BENZYLOXY-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(17825-15-9)
• EPA Substance Registry System: 7-BENZYLOXY-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(17825-15-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 17825-15-9(Hazardous Substances Data)

Usage

General Description

7-BENZYLOXY-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is a chemical compound that belongs to the quinoline family. It is a derivative of 4-hydroxyquinoline and contains a benzyl group, as well as an ethyl ester functional group. This chemical has potential applications in pharmaceuticals and as a synthetic intermediate in organic chemistry. It may also have biological activity due to its structural similarity to other bioactive quinoline compounds. Further research and testing would be needed to fully understand the potential uses and effects of this compound.

InChI:InChI=1/C19H17NO4/c1-2-23-19(22)16-11-20-17-10-14(8-9-15(17)18(16)21)24-12-13-6-4-3-5-7-13/h3-11H,2,12H2,1H3,(H,20,21)

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 1484-26-0 3-(benzyloxy)aniline 
• 17825-16-0 diethyl <<3-(benzyloxy)anilino>methylene>malonate 

Downstream Products

• 869358-09-8 ethyl 1-ethyl-7-{[2-({2-[(2-azidoethyl)oxy]ethyl}oxy)ethyl]oxy}-4-oxo-1,4-dihydro-quinoline-3-carboxylate 
• 869358-08-7 ethyl 1-ethyl-7-{[2-({2-[(2-hydroxyethyl)oxy]ethyl}oxy)ethyl]oxy}-4-oxo-1,4-dihydro-quinoline-3-carboxylate 
• 869358-11-2 1-ethyl-7-{[2-({2-[(2-aminoethyl)oxy]ethyl}oxy)ethyl]oxy}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 797793-72-7 7-(2-amino-ethoxy)-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid sodium salt 
• 797793-70-5 7-(2-dibenzylamino-ethoxy)-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 797793-71-6 7-(2-amino-ethoxy)-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 797793-69-2 1-ethyl-7-hydroxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 797793-68-1 7-benzyloxy-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 161405-23-8 ethyl 6-(benzyloxy)-4-chloroquinolone-3-carboxylate 
• 19501-17-8 ethyl 7-(benzyloxy)-4-chloroquinolone-3-carboxylate 

Relevant articles and documents

Computer-Aided Molecular Modeling, Synthesis, and Biological Evaluation of 8-(Benzyloxy)-2-phenylpyrazoloquinoline as a Novel Benzodiazepine Receptor Agonist Ligand

Using computer-aided conformational analysis, based on molecular dynamics simulation, cluster analysis, and Monte Carlo techniques, we have designed and synthesized compounds in which a benzyloxy substituent has been incorporated into a series of pyrazoloquinoline benzodiazepine receptor (BZR) ligands.Earlier studies had shown that the benzyloxy group could act as part of the agonist pharmacophoric determinant in the β-carboline ring system.Furthermore, the agonist β-carboline had been correlated with a binding site orientation and volume fit for an agonist 6-phenylimidazobenzodiazepine carboxylate.The present study was undertaken to determine whether the benzyloxy substituent could be used as an agonist pharmacophoric descriptor for the phenylpyrazoloquinolin-3-one BZR ligands.The results of a determination of GABA shift ratios for the synthetic ligands indicate that 8-(benzyloxy)-2-phenylpyrazoloquinolin-3-one can be predicted to be an agonist at the BZR.