178421-71-1Relevant articles and documents
Asymmetric synthesis of ES-285, an anticancer agent isolated from marine sources
Allepuz, Ana C.,Badorrey, Ramon,Diaz-de-Viliegas, Maria D.,Galvez, Jose A.
experimental part, p. 6172 - 6178 (2010/03/26)
The asymmetric synthesis of (2S,3R)-2-amino-3-octane-decanol hydrochloride (ES-285-HC1) was achieved in eight steps in ca. 38% overall yield from the N-benzylimine-derived from. (R)-2,3-O-isopropylidene glyceraldehyde, which is easily available on gram sc