17920-15-9

Basic information

• Product Name: Dimethyl-(p-tolyl)silanol
• Synonyms: Dimethyl-(p-tolyl)silanol;Dimethyl (p-tolyl)silanol,95%;Dimethyl (p-tolyl)silanolDimethyl (4-methylphenyl)silanol
• CAS NO: 17920-15-9
• Molecular Formula: C₉H₁₄OSi
• Molecular Weight: 166.29236
• Mol File: 17920-15-9.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Dimethyl-(p-tolyl)silanol(CAS DataBase Reference)
• NIST Chemistry Reference: Dimethyl-(p-tolyl)silanol(17920-15-9)
• EPA Substance Registry System: Dimethyl-(p-tolyl)silanol(17920-15-9)

Safety Data

• Hazardous Substances Data: 17920-15-9(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

Upstream product

• 17881-63-9 chlorodimethyl(4-methylphenyl)silane 
• 56633-16-0 1,1-dimethylphenylmethylsilanol 
• 1432-39-9 dimethyl-p-tolylsilane 
• 106-38-7 para-bromotoluene 
• 17988-22-6 ethoxy(dimethyl)(p-tolyl)silane 
• 541-05-9 Hexamethylcyclotrisiloxane 
• 51501-87-2 dimethyl(4-methylphenyl)methoxysilane 

Downstream Products

• 123248-21-5 (E)-n-butyl 3-(p-tolyl)acrylate 
• 613-33-2 (4,4'-dimethyl-1,1'-biphenyl) 
• 17555-94-1 (E)-4'-methoxy-4-methylstilbene 
• 51501-87-2 dimethyl(4-methylphenyl)methoxysilane 
• 67-56-1 methanol 
• 66870-89-1 1,1,1-trimethyl-3,3-dimethyl-3-tolyldisiloxane 
• 104144-48-1 C₂₂H₃₉ClO₄Si₅ 

Relevant articles and documents

METHOD OF PREPARING SILANOLS WITH SELECTIVE CYTOCHROME P450 VARIANTS AND RELATED COMPOUNDS AND COMPOSITIONS

This disclosure provides a method of preparing a silanol-functional organosilicon compound with a cytochrome P450 variant that facilitates the oxidization of a silyl hydride group to a silanol group in the presence of oxygen. The method includes combining the cytochrome P450 variant and an organosilicon compound having at least one silicon-bonded hydrogen atom to give a reaction mixture and exposing the reaction mixture to oxygen to oxidize the organosilicon compound, thereby preparing the silanol-functional organosilicon compound. Cytochrome P450 variants suitable for use in the method are also disclosed, along with methods for engineering and optimizing the same. Nucleic acids encoding the cytochrome P450 variants and compositions, expression vectors, and host cells including the same are also disclosed.

Selective Enzymatic Oxidation of Silanes to Silanols

Compared to the biological world's rich chemistry for functionalizing carbon, enzymatic transformations of the heavier homologue silicon are rare. We report that a wild-type cytochrome P450 monooxygenase (P450BM3 from Bacillus megaterium, CYP102A1) has promiscuous activity for oxidation of hydrosilanes to give silanols. Directed evolution was applied to enhance this non-native activity and create a highly efficient catalyst for selective silane oxidation under mild conditions with oxygen as the terminal oxidant. The evolved enzyme leaves C?H bonds present in the silane substrates untouched, and this biotransformation does not lead to disiloxane formation, a common problem in silanol syntheses. Computational studies reveal that catalysis proceeds through hydrogen atom abstraction followed by radical rebound, as observed in the native C?H hydroxylation mechanism of the P450 enzyme. This enzymatic silane oxidation extends nature's impressive catalytic repertoire.

A discrete octahedrally shaped [Ag6]4+ cluster encapsulated within silicotungstate ligands

By the reaction of TBA4H4[γ-SiW 10O36] (TBA = tetra-n-butylammonium) with AgOAc (OAc = acetate) using dimethylphenylsilane as a reductant in acetone, a unique polyoxometalate containing a discrete octahedrally shaped [Ag6] 4+ cluster, TBA8[Ag6(γ-H 2SiW10O36)2]·5H2O, could be synthesized, and the molecular structure was determined.