1794-48-5

Basic information

• Product Name: Benzene,(3-bromo-1-propynyl)-
• Synonyms: 3-phenyl-prop-2-ynyl bromide;(3-Bromo-1-propynyl)benzene;Benzene, (3-bromo-1-propynyl)-;1-bromo-3-phenyl-2-propyne;3-Bromo-1-phenylpropyne;3-phenylpropargyl bromide;1-phenyl-3-bromo-1-propyne
• CAS NO: 1794-48-5
• Molecular Formula: C9H7Br
• Molecular Weight: 195.059
• Mol File: 1794-48-5.mol
• Article Data: 75

Chemical Properties

• Boiling Point: 106-107 °C(Press: 15 Torr)
• Flash Point: 4℃
• Density: 1.377 g/cm3(Temp: 11.5 °C)
• CAS DataBase Reference: Benzene,(3-bromo-1-propynyl)- (CAS DataBase Reference)
• NIST Chemistry Reference: Benzene,(3-bromo-1-propynyl)- (1794-48-5)
• EPA Substance Registry System: Benzene,(3-bromo-1-propynyl)- (1794-48-5)

Safety Data

• Statements: 878435
• Safety Statements: 878435
• HazardClass: 878435
• Hazardous Substances Data: 1794-48-5(Hazardous Substances Data)

Upstream product

• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 558-13-4 carbon tetrabromide 
• 178425-56-4 1,1,2-tribromo-2-phenylcyclopropane 
• 591-50-4 iodobenzene 
• 536-74-3 phenylacetylene 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 7789-60-8 phosphorus tribromide 
• 50874-14-1 phenylpropargyl bromide 
• 25724-96-3 2-<(3-Phenyl-2-propynyl)oxy>-3,4,5,6-tetrahydro-2H-pyran 
• 106-96-7 propargyl bromide 
• 108-86-1 bromobenzene 
• 164859-37-4 C₁₅H₁₂Br₂Se 
• 82490-61-7 3-phenyl-2-propyn-1-yl methanesulfonate 
• 50-00-0 formaldehyd 

Downstream Products

• 16900-65-5 1,7-diphenyl-4,4-bis(ethoxycarbonyl)hepta-1,6-diyne 
• 101585-55-1 formylamino-(3-phenyl-prop-2-ynyl)-malonic acid diethyl ester 
• 93006-71-4 2-(3-phenylprop-2-ynyl)malonic acid diethyl ester 
• 67546-61-6 2-acetyl-5-phenylpent-2-en-4-ynoic ethylester 
• 95158-94-4 ethyl 2-benzoyl-5-phenyl-4-pentynoate 
• 96273-12-0 2-benzoyl-5-phenyl-2-(3-phenyl-prop-2-ynyl)-pent-4-ynoic acid ethyl ester 
• 92863-03-1 4-Methyl-1-phenyl-heptin-⁽¹⁾-ol-⁽⁴⁾ 
• 13702-03-9 phenyl (3-phenylprop-2-yn-1-yl) sulfide 
• 72040-23-4 1-(3-phenyl-prop-2-ynyl)-1H-arsinin-4-one 
• 6088-98-8 1-Phenyl-nonadiin-(1,4) 
• 67546-56-9 1-<3-Phenyl-propargyl>-1-acetyl-aceton 
• 13702-05-1 1-Aethylthio-3-phenyl-prop-2-in 
• 79841-53-5 1-(3-phenylprop-2-ynyl)-1-azoniabicyclo<2.2.2>octan-3-one bromide 
• 79841-52-4 2-methyl-2-(3-phenylprop-2-ynyl)-4-oxo-1,2,3,4-tetrahydroisoquinolinium bromide 

Relevant articles and documents

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Copper(I)-Catalyzed Intramolecular Cyclization of o-Propargyloxy Diketopiperazines to Access Diverse Diazabicyclic and Spiro-Diketopiperazinochromanes

In this report, two distinctive intramolecular cyclizations of o-propargyloxy diketopiperazines (achieved from a one-pot Ugi post-transformation) is achieved via a copper(I)-catalyzed intramolecular reaction of azomethine ylide and alkyne moiety. The presence of internal alkyne in the starting materials directed the reaction towards through [3+2]-cycloaddition, while terminal alkyne led to a spirocyclization reaction between azomethine ylide and terminal unsaturated C?C bond. This method offering an opportunity for the synthesis of challenging Diazabicyclics and Spiro-Diketopiperazinochromanes in high yields with exclusive diastereoselectivity. (Figure presented.).

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Iron-Catalyzed [2+2+2] Annulation of Aliphatic Bridged 1,n-Enynes with Aldehydes for the Synthesis of Fused Pyrans

An iron-catalyzed [2+2+2] annulation of aliphatic bridged 1,n-enynes with aldehydes was developed. Aldehydes play a dual role as the precursors of acyl radicals to trigger the cascade cyclization but also as the radical acceptors to terminate the annulation. This two-in-one strategy overcomes the limitation in [2+2+m] cyclization that requires a rigid benzene skeleton as the essential linker, thus enabling the efficient synthesis of functionalized fused [5.6] and [6.6] pyran skeletons.