180181-33-3

Basic information

• Product Name: 3,3-dimethyl-4-(4-methoxyphenyl)-azetidin-2-one
• Synonyms: 3,3-dimethyl-4-(4-methoxyphenyl)-azetidin-2-one
• CAS NO: 180181-33-3
• Molecular Weight: 205.257
• Mol File: 180181-33-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,3-dimethyl-4-(4-methoxyphenyl)-azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-dimethyl-4-(4-methoxyphenyl)-azetidin-2-one(180181-33-3)
• EPA Substance Registry System: 3,3-dimethyl-4-(4-methoxyphenyl)-azetidin-2-one(180181-33-3)

Safety Data

• Hazardous Substances Data: 180181-33-3(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 97-62-1 Ethyl isobutyrate 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 64187-51-5 N-trimethylsilyl(4-methoxy)benzaldimine 
• 874-90-8 4-methoxybenzonitrile 
• 949096-25-7 C₁₄H₂₄BNO 

Downstream Products

• 154780-86-6 1-Hydroxymethyl-4-(4-methoxy-phenyl)-3,3-dimethyl-azetidin-2-one 

Relevant articles and documents

Direct and practical Gilman-Speeter synthesis of 3,4-trisubstituted β-lactams via the Thorpe-Ingold effect

A highly efficient Gilman-Speeter synthesis of 3,4-trisubstituted β-lactams possessing a 4-aryl substituent is described, employing a direct, uncatalyzed Mannich reaction between TMS imines and TMS ketene acetals. The process avoids cryogenic conditions, making it more amenable to process-scale use than related methods for β-lactam synthesis. A Gilman-Speeter diastereoselective version using a sulfinyl imine and leading to homochiral sulfinyl β-aminoester is also presented.

Fibrinogen receptor antagonist and pharmaceutical compositions comprising the same

Compounds of the following general formula (I) and pharmaceutically acceptable salts thereof.