180200-86-6

Basic information

• Product Name: 4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULFONAMIDE
• Synonyms: 2-Chloro-4-(methylsulphonyl)benzyl bromide;1-(Bromomethyl)-2-chloro-4-(methylsulphonyl)benzene, 4-(Bromomethyl)-3-chlorophenyl methyl sulphone
• CAS NO: 180200-86-6
• Molecular Formula: C₈H₈BrClO₂S
• Molecular Weight: 283.56992
• Mol File: 180200-86-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 103-105
• Boiling Point: 408.8°Cat760mmHg
• Flash Point: 201°C
• Appearance: /
• Density: 1.642g/cm³
• Vapor Pressure: 1.61E-06mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULFONAMIDE(180200-86-6)
• EPA Substance Registry System: 4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULFONAMIDE(180200-86-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 180200-86-6(Hazardous Substances Data)

Usage

General Description

4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULIDAMIDE, also known as CPB-TPS, is a chemical compound that has been used in the development of pharmaceutical drugs. It is a piperidine derivative with a chloro and cyclopropyl group attached to the nitrogen atom. 4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULFONAMIDE has shown potential for use in the treatment of various medical conditions, including neurological disorders and pain management. It acts as a selective serotonin and norepinephrine reuptake inhibitor, making it a potential candidate for antidepressant and anxiolytic drugs. Additionally, it has also been studied for its potential analgesic properties. The unique structure of 4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULIDAMIDE makes it a promising candidate for further drug development and research.

InChI:InChI=1/C8H8BrClO2S/c1-13(11,12)7-3-2-6(5-9)8(10)4-7/h2-4H,5H2,1H3

Upstream product

• 101349-95-5 2-chloro-4-(methylsulfonyl)benzaldehyde 
• 84194-36-5 2-chloro-4-fluorobenzaldehyde 
• 181300-40-3 [2-chloro-4-(methylsulfonyl)phenyl]methanol 

Downstream Products

• 1033951-66-4 3-Chloro-4-{2-[1-(2-chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-pyrimidin-4-yloxy}-5-methyl-benzonitrile 
• 1033951-84-6 4-{2-[1-(2-Chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-5-fluoro-pyrimidin-4-yloxy}-3,5-dimethyl-benzonitrile 
• 1034013-11-0 4-{2-[1-(2-Chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-pyrimidin-4-ylamino}-3,5-dimethyl-benzonitrile 
• 1033954-34-5 4-{2-[8-(2-chloro-4-methanesulfonyl-benzyl)-8-aza-bicyclo[3.2.1]oct-3-ylamino]-pyrimidin-4-ylamino}-3,5-dimethyl-benzonitrile 
• 1033954-30-1 (E)-3-(4-{2-[1-(2-Chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-pyrimidin-4-ylamino}-3,5-dimethyl-phenyl)-acrylonitrile 
• 1394070-52-0 2-chloro-5-(2-chloro-4-(methylsulfonyl)benzyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine 
• 1021873-50-6 5-chloro-1-[2-chloro-4-(methylsulfonyl)benzyl]-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide 
• 932708-60-6 2-(2-chloro-4-methanesulfonylbenzyl)-3-oxopentanoic acid methyl ester 
• 932708-12-8 3-(2-chloro-4-methanesulfonylbenzyl)pentane-2,4-dione 
• 918524-57-9 [3-(2-chloro-4-methanesulfonyl-benzyloxy)-2-ethoxy-phenyl]-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone 
• 1033951-08-4 4-{5-Bromo-2-[1-(2-chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-pyrimidin-4-yloxy}-3,5-dimethyl-benzonitrile 
• 1033951-24-4 4-{2-[1-(2-chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-pyrimidin-4-yloxy}-3,5-dimethyl-benzonitrile 

Relevant articles and documents

Piperidine compound and preparation method and medical application thereof

The invention discloses a piperidine compound shown as a formula (I) and a preparation method and medical application thereof, and particularly relates to a piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof and a preparation method and application of the piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof. The compound provided by the invention can inhibit the activity of USP7 enzyme, has very good selectivity and druggability, and can be used for preparing medicines for preventing or treating tumor diseases or virus infectious diseases.

Non-nucleoside reverse transcriptase inhibitors

The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1, R2, R3, R4, R5a, R5b, R6a, R6b and X are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.

ORGANIC COMPOUNDS

There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.