181300-40-3

Basic information

• Product Name: (2-CHLORO-4-METHANESULFONYL-PHENYL)-METHANOL
• Synonyms: RARECHEM AL BD 1445;(2-CHLORO-4-METHANESULFONYL-PHENYL)-METHANOL;(2-Chloro-4-methylsulfonylphenyl)methanol;Benzenemethanol, 2-chloro-4-(methylsulfonyl)-
• CAS NO: 181300-40-3
• Molecular Formula: C₈H₉ClO₃S
• Molecular Weight: 220.67
• Mol File: 181300-40-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-CHLORO-4-METHANESULFONYL-PHENYL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-4-METHANESULFONYL-PHENYL)-METHANOL(181300-40-3)
• EPA Substance Registry System: (2-CHLORO-4-METHANESULFONYL-PHENYL)-METHANOL(181300-40-3)

Safety Data

• Hazardous Substances Data: 181300-40-3(Hazardous Substances Data)

Usage

General Description

(2-CHLORO-4-METHANESULFONYL-PHENYL)-METHANOL is a chemical compound with the molecular formula C8H9ClO3S. It is a white to off-white crystalline solid that is used in the synthesis of pharmaceutical compounds and as an intermediate in organic synthesis. (2-CHLORO-4-METHANESULFONYL-PHENYL)-METHANOL is known for its potential use in the development of drugs for various medical applications. It is important to handle this chemical with care and follow proper safety protocols due to its potential hazards.

Upstream product

• 84194-36-5 2-chloro-4-fluorobenzaldehyde 
• 53250-83-2 2-chloro-4-(methanesulfonyl)benzoic acid 
• 101349-95-5 2-chloro-4-(methylsulfonyl)benzaldehyde 

Downstream Products

• 180200-86-6 1-(bromomethyl)-2-chloro-4-(methylsulfonyl)benzene 
• 219764-95-1 2-Chloro-4-(methanesulfonyl)-1-((methanesulfonyloxy)methyl)benzene 
• 101349-95-5 2-chloro-4-(methylsulfonyl)benzaldehyde 

Relevant articles and documents

Synthesis and crystal structure of [2-Chloro-4-(methylsulfonyl)phenyl]methanol

The crystal structure of the [2-chloro-4-(methylsulfonyl)phenyl]methanol has been determined by single crystal X-ray diffraction method. The crystal belongs to monoclinic, space group P2(1)/c, with a = 8.208(4), b = 4.870 (2), c = 23.349 (10) ?, α = 90, β = 97.160 (6), γ = 90°, V = 926.0 (7)?3, Z = 4, Dx= 1.583 Mg/m3, λ(MoKa) = 0.71073, F(000) = 456, μ(MoKα) = 0.607 mm-1, R = 0.0506 and wR = 0.1231 for 0.1263 reflections with I > 2σ (I). The S atom has a distorted tetrahedral geometry with bond angles ranging from 103.03 (12)° to 118.13 (13)°. The crystal structure is stabilized by intermolecular hydrogen bonds and p-p stacking interactions.

ANTIPROLIFERATION COMPOUNDS AND USES THEREOF

The present invention provides compounds of Formula I′, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Click reaction as a tool to combine pharmacophores: The case of Vismodegib

Abstract The design and the preparation of a small library of 1,4-diphenyl-1,2,3-triazole derivatives is reported, with the aim to obtain a new class of Hedgehog pathway inhibitors. The smoothened protein is part of the hedgehog signaling pathway that is