180534-17-2

Basic information

• Product Name: Trifluoro-methanesulfonic acid (5R,10S)-9-benzyl-10-(4-fluoro-phenyl)-1,6-dioxa-9-aza-spiro[4.5]dec-3-en-3-yl ester
• Synonyms: Trifluoro-methanesulfonic acid (5R,10S)-9-benzyl-10-(4-fluoro-phenyl)-1,6-dioxa-9-aza-spiro[4.5]dec-3-en-3-yl ester
• CAS NO: 180534-17-2
• Molecular Weight: 473.445
• Mol File: 180534-17-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Trifluoro-methanesulfonic acid (5R,10S)-9-benzyl-10-(4-fluoro-phenyl)-1,6-dioxa-9-aza-spiro[4.5]dec-3-en-3-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Trifluoro-methanesulfonic acid (5R,10S)-9-benzyl-10-(4-fluoro-phenyl)-1,6-dioxa-9-aza-spiro[4.5]dec-3-en-3-yl ester(180534-17-2)
• EPA Substance Registry System: Trifluoro-methanesulfonic acid (5R,10S)-9-benzyl-10-(4-fluoro-phenyl)-1,6-dioxa-9-aza-spiro[4.5]dec-3-en-3-yl ester(180534-17-2)

Safety Data

• Hazardous Substances Data: 180534-17-2(Hazardous Substances Data)

Upstream product

• 503537-22-2 3-[(S)-4-Benzyl-3-(4-fluoro-phenyl)-2-hydroxy-morpholin-2-yl]-propane-1,2-diol 
• 503537-21-1 (S)-2-Allyl-4-benzyl-3-(4-fluoro-phenyl)-morpholin-2-ol 
• 159706-87-3 4-benzyl-3-(4-fluorophenyl)morpholin-2-one 
• 145100-51-2 N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide 
• 180534-16-1 (5R,10S)-9-Benzyl-10-(4-fluoro-phenyl)-1,6-dioxa-9-aza-spiro[4.5]decan-3-one 

Downstream Products

• 195605-08-4 (3S,5S,10S)-10-(4-Fluoro-phenyl)-3-[2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl)-phenyl]-1,6-dioxa-9-aza-spiro[4.5]decane 
• 195605-26-6 (5S,10S)-9-Benzyl-10-(4-fluoro-phenyl)-3-[2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl)-phenyl]-1,6-dioxa-9-aza-spiro[4.5]dec-3-ene 

Relevant articles and documents

Spirocyclic NK1 antagonists I: [4.5] and [5.5]-Spiroketals

A series of novel spiroketal-based NK1 antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.