180715-66-6

Basic information

• Product Name: (R)-4-Benzyloxyphenyl-N-methylglycinamide
• CAS NO: 180715-66-6
• Molecular Weight: 270.331
• Mol File: 180715-66-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-4-Benzyloxyphenyl-N-methylglycinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-Benzyloxyphenyl-N-methylglycinamide(180715-66-6)
• EPA Substance Registry System: (R)-4-Benzyloxyphenyl-N-methylglycinamide(180715-66-6)

Safety Data

• Hazardous Substances Data: 180715-66-6(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 69489-40-3 D-2-[p-(benzyloxy)phenyl]glycine 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 71336-83-9 Methyl-D-p-benzyloxyphenylglycinat 
• 74-89-5 methylamine 

Downstream Products

• 201608-19-7 (2R,5R)-1-Benzoyl-5-(4-benzyloxyphenyl)-2-tert-butyl-3-methylimidazolidin-4-one 
• 201608-22-2 [4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-phenyl]-phosphonic acid diethyl ester 
• 201608-23-3 4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzonitrile 
• 169209-65-8 MPPG 
• 201608-21-1 Trifluoro-methanesulfonic acid 4-((2R,4S)-3-benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-phenyl ester 
• 201608-20-0 (2R,5S)-1-Benzoyl-5-(4-benzyloxyphenyl)-2-(tert-butyl)-3,5-dimethylimidazolidin-4-one 
• 201608-24-4 4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzoic acid ethyl ester 

Relevant articles and documents

Stereoselective synthesis of (S)-MPPG, (S)-MTPG and (S)-(+)-αM4CPG from (R)-4-hydroxyphenylglycine

(R)-4-Hydroxyphenylgrycine was protected with a benzyl group and a methyl group was introduced at the α position by using the self-regeneration-of-stereocentre method. After the 4-hydroxy group had been converted into the corresponding trifluoromethanesulfonate (triflate), three palladium-catalyzed reactions were employed to furnish (S)-α-methyl-4-phosphonophenylglycine [(S)-MPPG], (S)-α-methyl-4-(tetrazol-5-yl)phenylglycine [(S)-MTPG] and (S)-4-carboxyphenyl-α-methylglycine [(S)-αM4CPG], a class of new and selective antagonists of metabotropic glutamate receptors.