71336-83-9Relevant articles and documents
Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as α-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies
Bello, Claudia,Cea, Michele,Bello, Giovanna Dal,Garuti, Anna,Rocco, Ilaria,Cirmena, Gabriella,Moran, Eva,Nahimana, Aimable,Duchosal, Michel A.,Fruscione, Floriana,Pronzato, Paolo,Grossi, Francesco,Patrone, Franco,Ballestrero, Alberto,Dupuis, Marc,Sordat, Bernard,Nencioni, Alessio,Vogel, Pierre
experimental part, p. 3320 - 3334 (2010/07/05)
Novel α-mannosidase inhibitors of the type (2R,3R,4S)-2-({[(1R)-2-hydroxy-1-arylethyl]amino}methyl)pyrrolidine-3,4-diol have been prepared and assayed for their anticancer activities. Compound 30 with the aryl group = 4-trifluoromethylbiphenyl inhibits the proliferation of primary cells and cell lines of different origins, irrespective of Bcl-2 expression levels, inducing a G2/Mcell cycle arrest and by modification of genes involved in cell cycle progression and survival.
Stereoselective synthesis of (S)-MPPG, (S)-MTPG and (S)-(+)-αM4CPG from (R)-4-hydroxyphenylglycine
Ma, Dawei,Tian, Hongqi
, p. 3493 - 3496 (2007/10/03)
(R)-4-Hydroxyphenylgrycine was protected with a benzyl group and a methyl group was introduced at the α position by using the self-regeneration-of-stereocentre method. After the 4-hydroxy group had been converted into the corresponding trifluoromethanesulfonate (triflate), three palladium-catalyzed reactions were employed to furnish (S)-α-methyl-4-phosphonophenylglycine [(S)-MPPG], (S)-α-methyl-4-(tetrazol-5-yl)phenylglycine [(S)-MTPG] and (S)-4-carboxyphenyl-α-methylglycine [(S)-αM4CPG], a class of new and selective antagonists of metabotropic glutamate receptors.
Total synthesis of monocyclic β-lactam antibiotics, nocardicin A and D
Kamiya,Hashimoto,Nakaguchi,Oku
, p. 323 - 328,324, 326 (2007/10/06)
-